Do Atrial Fibrillation–Promoting Gene Variants Act by Enhancing Atrial Remodeling?

Nattel, Stanley; Aguilar, Martín

doi:10.1016/j.jacep.2020.07.008

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Experimental results showed that the expression of PITX2c was positively and negatively correlated with I Ks and I CaL densities, respectively. Interestingly, genetic heritability may be mediated via definable atrial remodeling in chronic AF [ 63 , 64 ].…”

Section: The Role Of Pitx2 In Cardiogenesis and Arrhythmogenesismentioning

confidence: 99%

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

Bai

Zhu

et al. 2021

IJMS

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Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause AF in patients, including genetic predispositions to AF development. Genome-wide association studies have identified a number of genetic variants in association with AF populations, with the strongest hits clustering on chromosome 4q25, close to the gene for the homeobox transcription PITX2. Because of the inherent complexity of the human heart, experimental and basic research is insufficient for understanding the functional impacts of PITX2 variants on AF. Linking PITX2 properties to ion channels, cells, tissues, atriums and the whole heart, computational models provide a supplementary tool for achieving a quantitative understanding of the functional role of PITX2 in remodelling atrial structure and function to predispose to AF. It is hoped that computational approaches incorporating all we know about PITX2-related structural and electrical remodelling would provide better understanding into its proarrhythmic effects leading to development of improved anti-AF therapies. In the present review, we discuss advances in atrial modelling and focus on the mechanistic links between PITX2 and AF. Challenges in applying models for improving patient health are described, as well as a summary of future perspectives.

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Section: The Role Of Pitx2 In Cardiogenesis and Arrhythmogenesismentioning

confidence: 99%

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

Bai

Zhu

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Experimental results showed that the expression of PITX2c was positively and negatively correlated with IKs and ICaL densities, respectively. Interestingly, genetic heritability may be mediated via definable atrial remodeling in chronic AF [84,85].…”

Section: Membrane Effector Genes Regulated By Pitx2mentioning

confidence: 99%

Understanding PITX2-dependent Atrial Fibrillation Mechanisms through Computational Models

Bai¹,

Lu²,

Zhu³

et al. 2021

Preprint

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Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are needed to reduce AF-associated morbidity and mortality. Several major mechanisms cause AF in patients, including a genetic predisposition to develop AF. Genome-wide association studies have identified genetic variants associated with AF populations, with the strongest hits clustering on chromosome 4q25, close to the gene coding for the homeobox transcription PITX2. Because of the inherent complexity of the human heart, experimental and basic research on PITX2-dependent AF is not sufficient for understanding atrial functional proprieties. Linking PITX2 to ion channels, cells, tissues, atria and the whole heart, computational models are necessary for achieving a quantitative understanding of atrial structure and function in PITX2-dependent AF. Computational approaches are used to capture all that we know about PITX2-dependent AF and to develop improved therapies. In the present review, we discuss advances in atrial modelling and focus on the mechanistic links between PITX2 and AF. Challenges in applying models for improving patient health are described, as well as a summary of future perspectives.

show abstract

Do Atrial Fibrillation–Promoting Gene Variants Act by Enhancing Atrial Remodeling?

Cited by 2 publications

References 22 publications

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

Understanding PITX2-Dependent Atrial Fibrillation Mechanisms through Computational Models

Understanding PITX2-dependent Atrial Fibrillation Mechanisms through Computational Models

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