Do Antipsychotics Limit Disability in Schizophrenia? A Naturalistic Comparative Study in the Community

Thirthalli, Jagadisha; Venkatesh, Basappa K.; Naveen, Magadi N.; G, Venkata Subramanian; Kumar, Kamalini; Gangadhar, B. N.

doi:10.1177/0975156420060205

Cited by 10 publications

(9 citation statements)

References 1 publication

(1 reference statement)

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“…This finding was in line with the studies conducted in China 41% [ 4 ], and other research conducted in China 37 %, 44% in men and women respectively [ 5 ], in India 41% [ 6 ]. On the other hand, the findings of this study were lower than the previous studies undertaken in India 83% [ 7 ], Ranchi Institute of Neuropsychiatry and Allied science Ranchi, 88% [ 8 ], Thirthahalli Taluk of Shimoga District, Karnataka 62% [ 9 ], in Spain 67.6% [ 10 ] and Nigeria 78% [ 11 ]. The possible reason could be the instrument, sample size, and cultural difference.…”

Section: Discussioncontrasting

confidence: 92%

“…Specifically, the greater likelihood of disability occurred among those who used alcohol currently as compared with those respondents who did not use alcohol currently, which is similar to other study [ 9 ]. The evidence indicates that substance abuse severely complicates schizophrenia by causing relapse, hospitalization, disrupting behavior, creating familial problems, residential instability, decreased functional status, and medication noncompliance [ 13 ].…”

Section: Discussionsupporting

confidence: 87%

“…Despite long years of pharmacological and psychosocial interventions, schizophrenia remains one of the leading causes of disability [ 9 , 10 ] including poor self-care, inability to manage the tasks of daily living, social withdrawal, poor functioning in affinitive roles, and work incapacity [ 11 ]. A recent study comparing the functional disability between schizophrenia and bipolar disorder resulted in greater disability in schizophrenia than bipolar Disorder [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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The magnitude of disability in patients with schizophrenia in North West Ethiopia: A multicenter hospital-based cross-sectional study

Beyene

Legas

Azale

et al. 2021

Heliyon

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To assess the magnitude of disability and its associated factors among patients with schizophrenia in North West Ethiopia in selected hospitals, 2019. Design: Multicenter hospital-based cross-sectional study. Setting: Gondar, Felege Hiwot, and Debre Tabor hospitals. Participants: We recruit 420 participants for interviews using a systematic random sampling technique. Measurement: We collect the data by face-to-face interview. Disability was measured using the World Health Organization Disability Assessment Scale 2.0. Coded variables were entered into Epi data V.4.4.2 and exported to SPSS V.24 for analysis. Bivariate and multivariate logistic regressions with OR and 95% CI were employed. Result: A total of 423 participants were interviewed, with a response rate of 99.3%. The magnitude of disability in this study was 41.7 % (95 %CI: 36.9, 46.4). Current use of alcohol (AOR ¼ 2.47,n95CI; 1.36,4.48), being jobless (AOR ¼ 3.27, 95CI; 1.80, 5.93), had negative symptoms (AOR ¼ 13.05,95CI, 7.58,22.45), had 5 and more years of illness (AOR ¼ 2.75,95CI; 1.29,5.86), and had 5 and more years of untreated psychosis (AOR ¼ 3.78,95CI, 1.85,7.75) were predictors of disability. Conclusion and recommendation:The magnitude of disability in this study was 41.7 %. Avoidance of alcohol usage, early initiation of treatment, creating job opportunities, and giving special emphasis to patients having negative symptoms is recommended.

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Section: Discussioncontrasting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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The magnitude of disability in patients with schizophrenia in North West Ethiopia: A multicenter hospital-based cross-sectional study

Beyene

Legas

Azale

et al. 2021

Heliyon

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“…These factors can be considered in future research in this area. Patients treated at the community level are associated with lesser disability (Thirthalli et al 2010). These benefits can be maintained over extended periods of time (Thirthalli et al 2009).…”

Section: Discussionmentioning

confidence: 99%

A study of disability profile and burden in caregivers of stable schizophrenia patients

Modi¹,

Mehta²,

Chaudhary³

et al. 2020

nin

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Introduction: Schizophrenia is one of the most devastating disorders, leading to long-term and progressive disability in numerous individuals. Disability reflects an interaction between features of a person's body and of the society. In all treatments, family psycho-education is also very important as disability of schizophrenia leads to burden upon family members. Caregiver burden can be either objective or subjective. Objective burdens are behavioural phenomena: disruption of the social activities and financial difficulties. Subjective burdens comprise emotional strain on caregivers. Due to the chronic nature of the disease and the disability, patients with schizophrenia as a group need most care in social and economic areas. Aim of the study: To assess the level of burden in caregivers of stable schizophrenia patients and their relation with degree of disability in schizophrenia patients. It was a cross-sectional and observation study. Material and methods:The study was carried out with 154 stable patients of International Classification of Diseases diagnosed schizophrenia and their primary caregivers. The patients were evaluated on the Indian Disability Evaluation and Assessment Scale (IDEAS) and Positive and Negative Syndrome Scale (PANSS), and the Burden Assessment Schedule (BAS) was used for their primary caregiver. Results: Two thirds of schizophrenia patients who were stable on medication for at least 6 months and diagnosed with schizophrenia for at least 2 years had mild (70.12%) and the rest had moderate disability (29.87%). Greater burden of care was experienced with increasing age. Conclusions: Caregivers' burden has a direct correlation with overall disability. Deficiency in interaction, communication and employment leads to more burden of care, but not a deficiency in self-care.

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“…Thirthalli et al . [ 14 ] assessed disability in 182 community dwelling schizophrenia patients in Thirthalli taluk of Shimoga district of Karnataka using the Indian Disability Evaluation and Assessment Scale (IDEAS). Their aim was to compare disability of schizophrenia patients receiving continuous antipsychotic treatment with that among those who were not taking antipsychotics or taking irregular treatment.…”

Section: Introductionmentioning

confidence: 99%

Disabilities research in India

Chandrashekar

et al. 2010

Indian J Psychiatry

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The objective of this paper is to review all articles related to psychiatric disability that have been published in the Indian Journal of Psychiatry since its inception till date. We have also added up some more relevant literature in the area of mental disability of Indian psychiatric patients. Finally the article ends up with discussion related to challenges associated with mental disability, persons with Disability Act and future directions in the area of psychiatric disability.

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Do Antipsychotics Limit Disability in Schizophrenia? A Naturalistic Comparative Study in the Community

Cited by 10 publications

References 1 publication

The magnitude of disability in patients with schizophrenia in North West Ethiopia: A multicenter hospital-based cross-sectional study

The magnitude of disability in patients with schizophrenia in North West Ethiopia: A multicenter hospital-based cross-sectional study

A study of disability profile and burden in caregivers of stable schizophrenia patients

Disabilities research in India

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