Do Antidepressants Induce Psychosis in Children and Adolescents? A Naturalistic Study in Ambulatory Pediatric Population

Mosheva, Mariela; Mekori, Ehud; Kantor, Shir; Berg, Y.W.M.M. van den; Weizman, Abraham; Gothelf, Doron

doi:10.1089/cap.2015.0229

Cited by 7 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, depressive symptoms correlated with negative symptoms and general adverse events. This may be supported by a recent study on schizophrenia patients, which showed a beneficial effect of adjunctive antidepressants on depressive and negative symptoms (Helfer et al 2015), with a relatively low risk of exacerbation of psychosis and adverse effects (Helfer et al 2015;Mosheva et al 2016).…”

Section: Discussionmentioning

confidence: 70%

Mood Symptoms in Stabilized Patients With Schizophrenia: A Bipolar Type With Predominant Psychotic Features?

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 70%

Mood Symptoms in Stabilized Patients With Schizophrenia: A Bipolar Type With Predominant Psychotic Features?

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…In case of disagreement, discussions between the raters were conducted, until consensus was reached. We demonstrated effective retrospective completion of CGI-I scores based on chart reports in a previous studies in 22q11.2DS population (Green et al, 2012;Mosheva et al, 2016). See Method section, page 8 paragraph 1.…”

Section: Q1chow Was Polypharmacy Handled Statistically?mentioning

confidence: 61%

“…In case of disagreement, discussions between the raters were conducted, until consensus was reached. The completion of the CGI retrospectively based on chart reports has been successfully used by us in a previous studies in 22q11.2DS [18,19].…”

Section: Assessment Of Efficacy and Side Effects Of Stimulant Treatmentmentioning

confidence: 99%

Stimulant treatment effectiveness, safety and risk for psychosis in individuals with 22q11.2 deletion syndrome

Basel

Mosheva

Maeder

et al. 2021

Eur Child Adolesc Psychiatry

Self Cite

View full text Add to dashboard Cite

Objective: This study aimed to retrospectively evaluate an association between stimulant treatment for attention-deficit/hyperactivity disorder (ADHD) in individuals with 22q11.2DS and the development of psychotic disorders, to evaluate long-term effectiveness and safety of stimulant treatment in individuals with 22q11.2DS compared to individuals with idiopathic ADHD, and to explore effects of catechol-Omethyltransferase ( COMT) genotype on 22q11.2DS response to stimulants and risk of side effects. Methods: Rates of stimulant use and methylphenidate equivalent exposure were compared among individuals with 22q11.2DS, between 51 with psychotic disorders and a control group of 57 22q11.2DS without psychotic disorders, from Tel Aviv and Geneva. In addition, 44 individuals with 22q11.2DS and ADHD from Tel Aviv who initiated stimulants before age 18 years were compared to a control group of 35 ageand sex-matched controls with idiopathic ADHD, for treatment effectiveness (Clinical Global Impression Scale-Improvement), and rates of side effects. Results: Stimulant use history and methylphenidate equivalent exposure did not differ among individuals with 22q11.2DS, between those with and without psychotic disorders. The long-term retrospective follow-up (5.3 ± 4.1 years) of stimulant-treated individuals with 22q11.2DS showed a higher rate of significant clinical improvement of ADHD symptoms, compared to idiopathic ADHD individuals (p=.013), and similar side effect rates. There was no effect of the COMT genotype on response to stimulants or on any side effects.

show abstract

“…Nonetheless, this does not explain the dissociation from admission to pre‐ECT in the findings for depressive versus ED‐related symptomatology. In addition, the completion of the CGI‐S retrospectively, based on chart reports, has been successfully used by our group in a previous study assessing treatment response in children and adolescents with different psychiatric disorders, including affective disorders (Mosheva et al, ). Moreover, CGI‐S has been the only measure of mood improvement used, and no other standardized measures of mood have been administered.…”

Section: Discussionmentioning

confidence: 99%

A retrospective case series of electroconvulsive therapy in the management of comorbid depression and anorexia nervosa

Shilton

Enoch‐Levy

Giron

et al. 2019

Intl J Eating Disorders

Self Cite

View full text Add to dashboard Cite

Objective Major depressive disorder (MDD) is common in anorexia nervosa (AN), associated with worse outcome and greater suicide risk. Electroconvulsive therapy (ECT) is highly effective in the treatment of MDD refractory to antidepressive treatment. We describe a case series of female adolescents with AN receiving ECT for MDD resistant to treatment and/or with severe suicide risk. Method We retrospectively analyzed the files of all 30 adolescent females hospitalized in our department because of AN between 1998 and 2017 and treated with ECT. Severity of eating disorder (ED) and depressive symptoms was retrospectively assessed using the Clinical Global Impression‐Severity Scale. Results Patients were severely depressed and suicidal on admission. All were resistant to antidepressants. A significant deterioration in depression, with severe suicidality, occurred from admission to pre‐ECT, with concomitant improvement in ED symptoms and increase in body mass index (BMI). Significant improvement in depressive and ED symptoms and increase in BMI occurred following ECT, continuing to discharge. Adverse effects were mostly minimal. Fifty‐three percentage of the patients were rehospitalized within the first year after ECT, mostly because of deterioration of depression and attempted suicide. Several years after discharge, 46.6% of the patients had no evidence of depression, suicidality, and ED‐symptomatology, and another 23% had only evidence of ED symptomatology. Discussion ECT is safe and well tolerated in AN with severe comorbid treatment resistant MDD and/or with increased suicide risk. Many AN patients undergoing ECT may be remitted at long‐term follow‐up.

show abstract

Do Antidepressants Induce Psychosis in Children and Adolescents? A Naturalistic Study in Ambulatory Pediatric Population

Abstract: In contrast to the clinical impression of some clinicians, antidepressant treatment in pediatric ambulatory population was not associated with emergence of psychotic symptoms.

Cited by 7 publications

References 32 publications

Mood Symptoms in Stabilized Patients With Schizophrenia: A Bipolar Type With Predominant Psychotic Features?

Mood Symptoms in Stabilized Patients With Schizophrenia: A Bipolar Type With Predominant Psychotic Features?

Stimulant treatment effectiveness, safety and risk for psychosis in individuals with 22q11.2 deletion syndrome

A retrospective case series of electroconvulsive therapy in the management of comorbid depression and anorexia nervosa

Contact Info

Product

Resources

About