Do all the linear accelerators comply with the ICRU 91's constraints for stereotactic body radiation therapy treatments?

Biston, Marie-Claude; Dupuis, P.; Gassa, F.; Grégoire, V.

doi:10.1016/j.canrad.2019.07.137

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…This is, notably, the case of the stereotactic body radiation therapy (SBRT). Considering the great diversity of SBRT protocols, with various doses per fraction, number of fractions, dose gradient, etc., it appears more rigorous to describe SBRT from its physical features, i.e., as a RT modality delivering many non-coplanar minibeams converging to the tumor with sub-millimetric accuracy, as defined by the International Commission on Radiation Units and Measurements (ICRU) [1][2][3][4][5][6]. Particularly, hypofractionated SBRT has been shown to improve anti-tumor efficiency and decrease the volume of irradiated healthy tissues for numerous tumor indications, including spine metastasis [7][8][9], prostate cancer [10], liver metastasis [11], as well as lung carcinoma and metastasis [7,12,13].…”

Section: Introductionmentioning

confidence: 99%

Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

Le Reun,

Granzotto,

Pêtre

et al. 2023

Cancers

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Stereotactic body radiation therapy (SBRT) has made the hypofractionation of high doses delivered in a few sessions more acceptable. While the benefits of hypofractionated SBRT have been attributed to additional vascular, immune effects, or specific cell deaths, a radiobiological and mechanistic model is still needed. By considering each session of SBRT, the dose is divided into hundreds of minibeams delivering some fractions of Gy. In such a dose range, the hypersensitivity to low dose (HRS) phenomenon can occur. HRS produces a biological effect equivalent to that produced by a dose 5-to-10 times higher. To examine whether HRS could contribute to enhancing radiation effects under SBRT conditions, we exposed tumor cells of different HRS statuses to SBRT. Four human HRS-positive and two HRS-negative tumor cell lines were exposed to different dose delivery modes: a single dose of 0.2 Gy, 2 Gy, 10 × 0.2 Gy, and a single dose of 2 Gy using a non-coplanar isocentric minibeams irradiation mode were delivered. Anti-γH2AX immunofluorescence, assessing DNA double-strand breaks (DSB), was applied. In the HRS-positive cells, the DSB produced by 10 × 0.2 Gy and 2 Gy, delivered by tens of minibeams, appeared to be more severe, and they provided more highly damaged cells than in the HRS-negative cells, suggesting that more severe DSB are induced in the “SBRT modes” conditions when HRS occurs in tumor. Each SBRT session can be viewed as hyperfractionated dose delivery by means of hundreds of low dose minibeams. Under current SBRT conditions (i.e., low dose per minibeam and not using ultra-high dose-rate), the response of HRS-positive tumors to SBRT may be enhanced significantly. Interestingly, similar conclusions were reached with HRS-positive and HRS-negative untransformed fibroblast cell lines, suggesting that the HRS phenomenon may also impact the risk of post-RT tissue overreactions.

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Section: Introductionmentioning

confidence: 99%

Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

Le Reun,

Granzotto,

Pêtre

et al. 2023

Cancers

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La radiothérapie stéréotaxique au Maroc : état des lieux et compatibilité technologique avec les exigences minimales des recommandations internationales de bonne pratique

Lalya

Benchakroun

Sifat

et al. 2023

Cancer/Radiothérapie

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Intrafraction motion during CyberKnife® prostate SBRT: impact of imaging frequency and patient factors

Rose

Ebert

Mukwada

et al. 2022

Preprint

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Purpose: To determine the relationship between imaging frequencies and prostate motion during CyberKnife stereotactic body radiotherapy (SBRT) for prostate cancer. Methods: Intrafraction displacement data for 331 patients who received treatment with CyberKnife for prostate cancer were retrospectively analysed. Prostate positions were tracked with a large variation in imaging frequencies. The percent of treatment time that patients remained inside various motion thresholds for both real and simulated imaging frequencies was calculated. Results: 84,920 image acquisitions over 1635 fractions were analysed. Fiducial distance travelled between consecutive images were less than 2, 3, 5, and 10 mm for 92.4%, 94.4%, 96.2%, and 97.7% of all consecutive imaging pairs respectively. The percent of treatment time that patients received adequate geometric coverage increased with more frequent imaging intervals. No significant correlations between age, weight, height, BMI, rectal, bladder or prostate volumes and intrafraction prostate motion were observed. Conclusions: There are several combinations of imaging intervals and movement thresholds that may be suitable for consideration during treatment planning with respect to imaging and CTV-to-PTV margin calculation, resulting in adequate geometric coverage for approximately 95% of treatment time. Rectal toxicities and treatment duration need to be considered when implementing combinations clinically.

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Do all the linear accelerators comply with the ICRU 91's constraints for stereotactic body radiation therapy treatments?

Cited by 3 publications

References 15 publications

Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

Influence of the Hypersensitivity to Low Dose Phenomenon on the Tumor Response to Hypofractionated Stereotactic Body Radiation Therapy

La radiothérapie stéréotaxique au Maroc : état des lieux et compatibilité technologique avec les exigences minimales des recommandations internationales de bonne pratique

Intrafraction motion during CyberKnife® prostate SBRT: impact of imaging frequency and patient factors

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