Do acute phase markers explain body temperature and brain temperature after ischemic stroke?

Abstract

In reference to Rudick and Miller's editorial, "Multiple sclerosis or multiple possibilities: The continuing problem of misdiagnosis," Dr. Deisenhammer calls attention to the importance of CSF oligoclonal band analysis in difficult diagnostic cases. The authors agree but point out reasons for caution. Drs. Kano et al. ask whether lesion location had an effect on brain or body temperature in the study by Whiteley et al., "Do acute phase markers explain body temperature and brain temperature after ischemic stroke?"

An integrated multi-omics study to identify dynamic molecular alterations associated with acute brain injury

“…On the other hand, inflammatory cytokine (e.g. interleukin-6) is reported to be associated with elevated body temperature after stroke 47 . In this study, inflammation-related pathways such as interleukin-6 production, cytokine-mediated signaling pathway, and regulation of innate immune response are significantly changed in ABI brains.…”