Do 1,25-dihydroxyvitamin D3 receptors depend on vitamin K?

Сергеев, И. Н.; Спиричев, В. Б.

doi:10.1016/s0271-5317(89)80016-8

Cited by 5 publications

(4 citation statements)

References 14 publications

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“…They also reported that a high blood level of vitamin D 3 is necessary for vitamin K 2 to exert a satisfactorily inhibitory effect on bone loss. Sergeev and Spirichev [37] reported that the dissociation of the activated D 3 -cytosolic receptor complex was likely to occur in vitamin K deficiency. Hara et al [8] noted that a single administration of vitamin K 2 resulted in no significant improvement in bone mass, and the concurrent administration of vitamins K and D led to no significant improvement in bone mass at the end of the shaft of the femur, but did result in a significant improvement in the femoral shaft of OVX rats, based on bone density calculated from dry weight and volume, and bone mineral content and bone mineral density as determined by DXA.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss

Matsunaga

Sakou

1999

Calcif Tissue Int

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This study was designed to assess the effect of vitamin K and D supplementation on ovariectomy-induced bone loss. Female Sprague-Dawley rats aged 8-9 months were ovariectomized (OVX) or sham operated and divided into five experimental groups: (1) ovariectomy (OVX), (2) OVX plus vitamin K supplementation, (3) OVX plus vitamin D supplementation, (4) OVX plus vitamin K and vitamin D supplementation, and (5) sham operation. The trabecular bone area was estimated by bone histomorphometry by microradiography and histological examination. Bone loss in OVX plus vitamin K and vitamin D group was significantly reduced at both 7 and 14 weeks compared with the OVX group. No significant bone loss in OVX plus vitamin K or OVX plus vitamin D groups was found. A similar effect of vitamin K and D supplementation on ovariectomy-induced bone loss was recognized in histological examination. Our findings indicate that vitamins K and D may have a synergistic effect on reducing bone loss. This is valuable information for the treatment of bone loss in postmenopausal women with osteoporosis.

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Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss

Matsunaga

Sakou

1999

Calcif Tissue Int

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“…participates in the post-translation modification of the calcium-binding proteins, including the one whose synthesis (on a genetic level) is induced by the hormone-active form of vitamin D [21][22][23][24][25].…”

Section: Vitaminmentioning

confidence: 99%

To the Substantiation of the Joint Use of Vitamin D and the Rest of the 12 Vitamins Necessary for the Creation and Realization of the Vital Functions of its Hormone-Active Form (The Vitamin D + 12 Vitamins Approach)

Spirichev¹

2013

J. Nutr. Ther.

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The realization of the multiple vital functions of vitamin D in a human organism closely depends on the sufficient provision of the rest of the vitamins necessary for the creation of the hormone-active form of vitamin D, as well as on the normal realization of the vital biochemical and physiological processes it controls.The above report substantiates the expediency of the combined application of vitamin D and a complex including the rest of the 12 vitamins both for the medical treatment and prevention of diseases (the D + 12 vitamins approach).

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“…The I. 25 -(OH)2 vitamin D3 binding capacity in the cytosol of intestinal mucosa was also increased in these vitamin K deficient rats (Sergeev and Spirichev, 1989).…”

Section: Effect Of Dietary Vitamin K1 (K1) On Selected Plasma Charactmentioning

confidence: 76%

“…It was suggested that the carboxylation of VDR might regulate its binding to DNA (Sergee and Norman, 1992). Sergeev and Spirichev (1989) reported that feeding rats a diet without adequate menadione sodium bisulfite supplementation resulted in an increase in bound VDR in the crude chromatin fraction of intestinal mucosa. The I.…”

Section: Effect Of Dietary Vitamin K1 (K1) On Selected Plasma Charactmentioning

confidence: 99%

Effect of dietary vitamin K1 on selected plasma characteristics and bone ash and the requirement of vitamin K1 in young turkeys

Jin

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This manuscript has been reproduced from the microfilm master. UMI fHms the text directly from the original or copy sulxnitted. Thus, some thesis arxl dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of ttie copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print Meedthrough, substarKlard margins, and improper alignment can adversely affect rsproduction.In the unlikely event that the author dkJ not send UMI a complete manuscript and there are missing pages, these wiU be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletkm.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sectkHis with small overlaps.

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Do 1,25-dihydroxyvitamin D3 receptors depend on vitamin K?

Cited by 5 publications

References 14 publications

The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss

The Effect of Vitamin K and D Supplementation on Ovariectomy-Induced Bone Loss

To the Substantiation of the Joint Use of Vitamin D and the Rest of the 12 Vitamins Necessary for the Creation and Realization of the Vital Functions of its Hormone-Active Form (The Vitamin D + 12 Vitamins Approach)

Effect of dietary vitamin K1 on selected plasma characteristics and bone ash and the requirement of vitamin K1 in young turkeys

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