DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

Loaeza-Loaeza, Jaqueline; Cerecedo-Castillo, Angel Josué; Rodríguez-Ruiz, Hugo Alberto; Castro‐Coronel, Yaneth; Moral-Hernández, Oscar Del; Recillas‐Targa, Félix; Hernández-Sotelo, Daniel

doi:10.1038/s41598-022-24186-6

Cited by 4 publications

(2 citation statements)

References 95 publications

(101 reference statements)

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“…It appears that the methylation level of the IRF1 promoter can still be modified by some additional factors in different cellular contexts. For example, overexpression of the methyltransferase gene DNMT3B led to increased IRF1 gene methylation levels and repression of its expression [68]. In contrast, exposure of cells to the TET1 dioxygenase under IFN-γ-stimulated conditions could demethylate the IRF1 gene and activate its transcription.…”

Section: Transcriptional and Epigenetic Regulation Of Irf1mentioning

confidence: 99%

Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin

Perevalova,

Gulyaeva,

Pustylnyak

2024

IJMS

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IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was initially identified for its involvement in inflammatory processes, there is now evidence that it provides a function in carcinogenesis as well. IRF1 has been shown to affect several important antitumor mechanisms, such as induction of apoptosis, cell cycle arrest, remodeling of tumor immune microenvironment, suppression of telomerase activity, suppression of angiogenesis and others. Nevertheless, the opposite effects of IRF1 on tumor growth have also been demonstrated. In particular, the “immune checkpoint” molecule PD-L1, which is responsible for tumor immune evasion, has IRF1 as a major transcriptional regulator. These and several other properties of IRF1, including its proposed association with response and resistance to immunotherapy and several chemotherapeutic drugs, make it a promising object for further research. Numerous mechanisms of IRF1 regulation in cancer have been identified, including genetic, epigenetic, transcriptional, post-transcriptional, and post-translational mechanisms, although their significance for tumor progression remains to be explored. This review will focus on the established tumor-suppressive and tumor-promoting functions of IRF1, as well as the molecular mechanisms of IRF1 regulation identified in various cancers.

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Section: Transcriptional and Epigenetic Regulation Of Irf1mentioning

confidence: 99%

Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin

Perevalova,

Gulyaeva,

Pustylnyak

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Increased levels of DNMT3B, a de novo DNA methyltransferase, were a recurrent event detected in oral cancer tissues [ 52 , 53 , 54 , 55 ] as well as oral premalignant lesions [ 56 , 57 ], strongly supporting its role in tumorigenesis. In the vicinity of DNMT3B , an amplification hotspot comprising two stemness-related genes, ID1 and BCL2L1 ( Figure 4 C), is commonly found in human embryonic stem cell cultures.…”

Section: Noninvasive Epigenetic Biomarkers For Early Detection Of Hea...mentioning

confidence: 99%

The Way to Malignant Transformation: Can Epigenetic Alterations Be Used to Diagnose Early-Stage Head and Neck Cancer?

Lai

Chen

et al. 2023

Biomedicines

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Identifying and treating tumors early is the key to secondary prevention in cancer control. At present, prevention of oral cancer is still challenging because the molecular drivers responsible for malignant transformation of the 11 clinically defined oral potentially malignant disorders are still unknown. In this review, we focused on studies that elucidate the epigenetic alterations demarcating malignant and nonmalignant epigenomes and prioritized findings from clinical samples. Head and neck included, the genomes of many cancer types are largely hypomethylated and accompanied by focal hypermethylation on certain specific regions. We revisited prior studies that demonstrated that sufficient uptake of folate, the primary dietary methyl donor, is associated with oral cancer reduction. As epigenetically driven phenotypic plasticity, a newly recognized hallmark of cancer, has been linked to tumor initiation, cell fate determination, and drug resistance, we discussed prior findings that might be associated with this hallmark, including gene clusters (11q13.3, 19q13.43, 20q11.2, 22q11-13) with great potential for oral cancer biomarkers, and successful examples in screening early-stage nasopharyngeal carcinoma. Although one-size-fits-all approaches have been shown to be ineffective in most cancer therapies, the rapid development of epigenome sequencing methods raises the possibility that this nonmutagenic approach may be an exception. Only time will tell.

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The relationship between DNA methyltransferase 3B (DNMT3B) and miR 124-3pa expressions in bladder cancer tissues

Fawzy,

El Faiomy,

El Desoky

et al. 2023

Mol Biol Rep

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DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B

Cited by 4 publications

References 95 publications

Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin

Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin

The Way to Malignant Transformation: Can Epigenetic Alterations Be Used to Diagnose Early-Stage Head and Neck Cancer?

The relationship between DNA methyltransferase 3B (DNMT3B) and miR 124-3pa expressions in bladder cancer tissues

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