DNMT3a rs1550117 Polymorphism Association with Increased Risk of Helicobacter pylori Infection

Cao, Xueyuan; Jia, Zhifang; Cao, Donghui; Kong, Fei; Jin, Meishan; Suo, Jian; Jiang, Jing

doi:10.7314/apjcp.2013.14.10.5713

Cited by 18 publications

(14 citation statements)

References 30 publications

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“…Fan et al found that individuals with the AA homozygous genotype of rs1550117 in the DNMT3A promoter region had a sixfold increased risk of GC compared with the GG genotype carriers and that the A allele showed a twofold higher promoter activity compared with the G allele [85]. Our study showed that the rs1550117 AA bearers for DNMT3A have a twofold increased risk of previous infection of H. pylori, although we did not observe any association of rs1550117 with the risk of gastric cancer [88]. Other SNP sites of DNMT3A, including rs7560488 [87], rs36012910 [89] and rs13420827 [84], were also reported to be involved in gastric cancer risk although without consistent conclusions [84,88].…”

Section: Dna Methylationcontrasting

confidence: 77%

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

et al. 2016

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Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.

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Section: Dna Methylationcontrasting

confidence: 77%

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

et al. 2016

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“…Tumor sites and characteristics also contribute to heterogeneity. One cancer type may exhibit different etiologies, organ origins, and histological subtypes, such as Helicobacter pylori infection, which is a key factor contributing to gastric cancer (Cao et al, 2013). In this meta-analysis, the main source of heterogeneity may have originated from the study of Fan et al (2010), who examined gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that SNP rs1550117 (A>G) was associated with DNMT3A promoter activity (Fan et al, 2010). Studies have also investigated the association between DNMT3A polymorphisms and cancer risk (Fan et al, 2010;Sun et al, 2012;Yang et al, 2012;Zhao et al, 2012;Mostowska et al, 2013;Shivarov et al, 2013;Cao et al, 2013;Xu et al, 2013;Zhao et al, 2013). However, the heterogeneity of data collection and statistical results remain inconclusive because of inadequate sample sizes.…”

Section: Introductionmentioning

confidence: 99%

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis

et al. 2015

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ABSTRACT. Cancer is a major public health problem worldwide that involves complex processes and factors. For instance, methylation is important in tumorigenesis. DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. To clarify the role of DNMT3A polymorphisms in cancer, we conducted a meta-analysis of 2014 cases and 3089 control subjects. Odds ratios with 95% confidence intervals were estimated to evaluate the association between the DNMT3A -448A>G polymorphism and cancer risk. The results showed that DNMT3A may be a protective factor against all cancer types and colorectal cancer groups. Further studies should be conducted including different ethnicities and large population sizes to generate a comprehensive conclusion.

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“…A genome-wide association study suggests that host genetic factors confer susceptibility to H. pylori infection (Mayerle et al, 2013). Some polymorphisms are associated with the increased risk of H. pylori infection (Zhao et al, 2012;Cao et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status

Zhou

Zhang²,

Gao³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.

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DNMT3a rs1550117 Polymorphism Association with Increased Risk of Helicobacter pylori Infection

Cited by 18 publications

References 30 publications

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis

Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status

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