DNATwist: A Web-Based Tool for Teaching Middle and High School Students About Pharmacogenomics

Berlin, Dorit S.; Person, M G; Mittal, Anav; Oppezzo, Marily; Chin, Doris B.; Starr, Barry; Klein, Teri E.; Schwartz, David L.; Altman, Russ B.

doi:10.1038/clpt.2009.303

Cited by 9 publications

(7 citation statements)

References 4 publications

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“…Among the individual factors, we can infer that there are genetic information and the right to obtain and use that information. Given the real possibility and the powerful implications of the growth in the use of genetic information, it is necessary to educate the population in a general way, which, in addition to lacking basic notions of genetics and pharmacology, still needs to pay attention to ethical, family, social, legal and financial aspects that this information affects ( 53 ) .…”

Section: Discussionmentioning

confidence: 99%

Nurse empowerment through Pharmacogenetics

Moraes

Nunes

Coeli-Lacchini

et al. 2020

Rev. Latino-Am. Enfermagem

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Objective: to verify the existence of elements that justify the use of pharmacogenetics by the Brazilian nurse. Method: this is a quantitative, cross-sectional, observational, descriptive study, whose final sample was 67 individuals. The participants were healthy at the time of the study and reported a history of previous use and the occurrence of adverse effects by drugs commonly used and metabolized by CYP2C9. We collected 4 mL of venous blood for subsequent DNA extraction by salting out method and genotyping of the CYP2C9*2 and CYP2C9*3 polymorphisms, using Polymerase Chain Reaction in real time using Taqman assays. Results: the use of drugs metabolized by CYP2C9 was frequent (more than 75% of the individuals have already used between 2 or 4 of these drugs). Regarding adverse events, there were 19 perceived symptomatic occurrences associated with drugs metabolized by CYP2C9. The allele frequency of the polymorphism * 2 and * 3 in the population studied was 11.1% and 7.5%, respectively, and there was a coincidence between the presence of alleles of low enzyme activity and the occurrence of adverse effects. Conclusion: there are elements that justify the adoption of pharmacogenetics in the nursing care to reduce the occurrence of adverse reactions to drugs metabolized by CYP2C9.

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Section: Discussionmentioning

confidence: 99%

Nurse empowerment through Pharmacogenetics

Moraes

Nunes

Coeli-Lacchini

et al. 2020

Rev. Latino-Am. Enfermagem

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“…56 Other examples of online educational innovations include development of web-based learning tools to expose middle- and high-school students to pharmacogenomics concepts and educational partnerships with secondary and undergraduate educators to develop pharmacogenomics teaching resources. 57–59 …”

Section: Educational Approaches and Strategiesmentioning

confidence: 99%

Educational strategies to enable expansion of pharmacogenomics-based care

Weitzel

Aquilante

Johnson

et al. 2016

American Journal of Health-System Pharmacy

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Purpose Educational barriers hinder the widespread application of pharmacogenomics in clinical practice. This review summarizes requisite pharmacist competencies, educational standards, and the current state of pharmacogenomics education to propose best practice solutions for educators to meet the specific needs and challenges of this complex topic. Summary Consensus-based pharmacist competencies and clinical guidelines have been published to guide knowledge attainment and application of pharmacogenomics concepts. Pharmacogenomics education is often integrated into existing courses and increasingly, within required standalone courses within PharmD curricula. Continuing education programs and limited postgraduate residencies/fellowship training opportunities are available to practitioners. However, challenges in identifying the optimal structure and amount of coverage, limited number of faculty experts, and inadequate availability of advanced pharmacogenomics practice settings for experiential education are limiting. Fortunately, successful approaches are emerging for both students and practitioners. In pharmacy schools, strategies include early exposure through foundational courses, incorporation into practice-based therapeutics courses, and introductory and advanced pharmacy practice experiences. For practitioners, institution-specific training, online resources, education within clinical decision support tools, and certificate programs can supplement more robust structured post-graduate training programs. Recent data also show the success of shared curricula and participatory education models involving an opportunity for learners to undergo personal genomic testing first-hand. Conclusion The pharmacy profession has taken a leadership role in expanding student and practitioner education to meet the demands of precision medicine initiatives. Effective approaches to attain pharmacogenomics knowledge and to drive its appropriate application in clinical practice are increasingly available.

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“…Uma ferramenta on-line desenvolvida por Berlin e colaboradores [15] buscou ensinar noções básicas de farmacogenética para jovens do ensino médio da Califórnia nos EUA. Após a exposição ao "DNA twist" por 1 hora, 90% dos jovens acharam o conteúdo do site muito compreensível, o que foi confirmado pelo acerto de 80% das questões de um teste de conhecimentos sobre o assunto posteriormente aplicado.…”

Section: O Processo De Educar O Paciente Sobre Suas Características Iunclassified

“…Dada a real possibilidade e as poderosas implicações do crescimento do uso de medicamento e também de informações genéticas, é preciso educar a população de uma maneira geral, que, além de carecer de noções básicas de genética e farmacologia, ainda precisa atentar-se para os aspectos éticos, familiares, sociais, legais e financeiros que essas informações afetam [15].…”

Section: R E S U Lta D O Sunclassified

Experiences From an Extension Program: Awareness of the Population About the Importance and Use of Pharmacogenetics

Moraes¹,

Lacchini²

2017

Rev. Cult. Ext. USP

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A expressão "farmacogenética" indica a existência de variações na sequência de DNA que podem influenciar a maneira como o corpo responde aos medicamentos, tanto em relação à eficácia terapêutica quanto à ocorrência de reações adversas aos medicamentos. Apesar de muito bem estabelecida e aplicada internacionalmente, o uso da farmacogenética ainda não é uma realidade no Brasil, especialmente no SUS. O objetivo geral desse trabalho foi produzir uma cartilha informativa sobre farmacogenética e aplicar essa cartilha para a população frequentadora do campus da USP de Ribeirão Preto, e fornecer de forma gratuita aos participantes um exame genético com a determinação dos alelos *2 e *3 da enzima CYP2C9, tema da cartilha. O presente projeto de extensão foi feito em paralelo a uma pesquisa clínica cujos resultados serão submetidos para revistas científicas e não serão reproduzidos aqui. Os participantes receberam informações gerais sobre farmacogenética de forma oral, em seguida leram a cartilha e a avaliaram através de um questionário. Esse estudo mostrou que, com o uso de materiais e método simples, é possível trazer a farmacogenética até mesmo para leigos, e isto pode ser uma importante abordagem para estimular o uso dessas informações por profissionais da saúde.Palavras-chave: Citocromo P-450 CYP2C9. Farmacogenética. Efeitos Colaterais. Reações Adversas Relacionadas a Medicamentos. A B S T R A C TThe term "pharmacogenetics" indicates the existence of variations in the DNA sequence that may influence the way our body responds to drugs, both in terms of therapeutic efficacy and the occurrence of adverse drug reactions. Although very well established and applied internationally, the use of pharmacogenetics is not yet a reality in Brazil, especially in SUS. The general objective of this work was to produce an

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DNATwist: A Web-Based Tool for Teaching Middle and High School Students About Pharmacogenomics

Cited by 9 publications

References 4 publications

Nurse empowerment through Pharmacogenetics

Nurse empowerment through Pharmacogenetics

Educational strategies to enable expansion of pharmacogenomics-based care

Experiences From an Extension Program: Awareness of the Population About the Importance and Use of Pharmacogenetics

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