2023
DOI: 10.1128/aem.00505-23
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DnaK-Mediated Protein Deamidation: a Potential Mechanism for Virulence and Stress Adaptation in Cronobacter sakazakii

Abstract: Cronobacter sakazakii can cause disease in individuals of all ages, with infections in premature infants being particularly deadly and resulting in bacterial meningitis and sepsis with a high mortality rate. Our study demonstrates that dnaK in Cronobacter sakazakii plays a critical role in virulence, adhesion, invasion, and acid resistance.

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Cited by 6 publications
(2 citation statements)
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“…38 Additionally, the knockout of dnaK increased the deamidation of several proteins in C. sakazakii. 37 In this study, we discovered a connection between the envZ/ompR and protein deamidation. Proteins with increased deamidation after envZ/ ompR deletion are primarily involved in glucose metabolic processes, suggesting that the deletion of envZ/ompR may impair the function of glucose metabolism-related proteins.…”
Section: ■ Discussionmentioning
confidence: 80%
See 1 more Smart Citation
“…38 Additionally, the knockout of dnaK increased the deamidation of several proteins in C. sakazakii. 37 In this study, we discovered a connection between the envZ/ompR and protein deamidation. Proteins with increased deamidation after envZ/ ompR deletion are primarily involved in glucose metabolic processes, suggesting that the deletion of envZ/ompR may impair the function of glucose metabolism-related proteins.…”
Section: ■ Discussionmentioning
confidence: 80%
“…An association was found between protein deamidation and growth disadvantage in C. sakazakii in our previous studies. 37,38 Proteomic analysis was employed to investigate potential protein deamidation resulting from the knockout of the envZ/ ompR gene. It was observed that 196 proteins exhibited deamidation modifications, among which 17 proteins (8.6%) showed a significant increase in deamidation after envZ/ompR knockout (Figure 5A).…”
Section: Construction and Growth Characteristics Of The Envz/ompr Mut...mentioning
confidence: 99%