DNAJC25 as a tumor suppressor candidate gene in breast cancer

Acun, Tolga

doi:10.15671/hjbc.725263

Cited by 1 publication

(1 citation statement)

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“…In liver cancers, DNAJC25 mRNA expression is markedly reduced, while its overexpression induces apoptosis and inhibits colony formation of liver cancer cells [204]. In silico analyses suggest that DNAJC25 mRNA expression is also reduced in breast cancer tissues, and high DNAJC25 mRNA expression is correlated with favorable post-progression survival in breast cancer [205]. These results suggest the tumor suppressive role of DNAJC25, but the functional association of DNAJC25 with p53 remains to be elucidated.…”

Section: • Dnajc25mentioning

confidence: 98%

Regulation of p53 and Cancer Signaling by Heat Shock Protein 40/J-Domain Protein Family Members

Kaida

Iwakuma

2021

IJMS

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Heat shock proteins (HSPs) are molecular chaperones that assist diverse cellular activities including protein folding, intracellular transportation, assembly or disassembly of protein complexes, and stabilization or degradation of misfolded or aggregated proteins. HSP40, also known as J-domain proteins (JDPs), is the largest family with over fifty members and contains highly conserved J domains responsible for binding to HSP70 and stimulation of the ATPase activity as a co-chaperone. Tumor suppressor p53 (p53), the most frequently mutated gene in human cancers, is one of the proteins that functionally interact with HSP40/JDPs. The majority of p53 mutations are missense mutations, resulting in acquirement of unexpected oncogenic activities, referred to as gain of function (GOF), in addition to loss of the tumor suppressive function. Moreover, stability and levels of wild-type p53 (wtp53) and mutant p53 (mutp53) are crucial for their tumor suppressive and oncogenic activities, respectively. However, the regulatory mechanisms of wtp53 and mutp53 are not fully understood. Accumulating reports demonstrate regulation of wtp53 and mutp53 levels and/or activities by HSP40/JDPs. Here, we summarize updated knowledge related to the link of HSP40/JDPs with p53 and cancer signaling to improve our understanding of the regulation of tumor suppressive wtp53 and oncogenic mutp53 GOF activities.

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Section: • Dnajc25mentioning

confidence: 98%