Dna Typing of Genital Warts and Diagnosis of Sexual Abuse of Children

Fleming, K. A.; Venning, V A; Evans, Mark

doi:10.1016/s0140-6736(87)90987-1

Cited by 48 publications

(8 citation statements)

References 4 publications

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“…Mucosal HPV types affect the anogenital and aerodigestive tract while cutaneous types predominantly infect cutaneous epithelia and are rarely found at anogenital sites or within the oral mucosa. However, there are some exceptions, for example HPV‐2, ‐27 and ‐57, which can cause both cutaneous, oral and anogenital lesions in children 26–30 …”

Section: Human Papillomavirus Life Cyclementioning

confidence: 99%

Human papillomavirus molecular biology and pathogenesis

Sanclemente

Gill

2002

Acad Dermatol Venereol

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Human papillomavirus (HPV) infection is the most common sexually transmitted disease in the world and accounts for an estimated 11% of the global cancer incidence in women. HPV-16 is the most prevalent type detected in cervical cancer and along with types 18, 31, 33 and 45 has been classified as a class I carcinogen. In addition to cervical cancer, HPVs are also associated with the malignant transformation of other mucosal and skin cancers. Thus, the combination of the malignant potential of HPV and its high prevalence of infection confers to it an importance of generalized clinical and virological significance. The natural history of HPV infection with or without treatment varies from spontaneous regression to persistence. The most important mechanism for wart regression appears to be cell-mediated immunity. Cytokines released by keratinocytes or cells of the immune system may play a part in the induction of an effective immune response against HPV infection and the subsequent regression of lesions. This review discusses the molecular biology, pathogenesis and immunology of HPV infections.

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Section: Human Papillomavirus Life Cyclementioning

confidence: 99%

Human papillomavirus molecular biology and pathogenesis

Sanclemente

Gill

2002

Acad Dermatol Venereol

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“…The prevalence of genital warts in children is not known, but the HPV type in genital warts from 184 children have been analysed in studies published to date. These results are collated in Table 1: 57 % contained HPV 6 or 11, 15 % HPV 1-4, while the remaining 28 % were either negative or contained other types [6,7,9,[14][15][16][17][18][19][20][21][22][23][24]. There was however considerable variation in the proportion of warts containing HPV types 1-4 in each study.…”

Section: A6 60mentioning

confidence: 99%

Hand-genital transmission of genital warts? An analysis of prevalence data

et al. 1995

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The role of hand-genital transmission in the aetiology of genital warts is unclear. However this route is suggested by a number of observations including the relatively high proportion of genital warts in children which contain HPV types 1-4 (15% for children and 2% for adults). We compared two transmission models; one which assumes that hand-genital transmission occurs and one that it does not, and determined the conditions in which each model can reflect the available prevalence data. Hand-genital transmission provides a simple explanation of the observed differences in the proportions of genital warts containing HPV types 1-4 and 6/11 in children and adults. If hand-genital transmission does not occur, the observed difference could only be explained by an eightfold greater probability of transmission to children of types 1-4 than types 6/11, or by an eightfold greater duration of infection with types 1-4. Our findings provide support for the view that genital warts may be transmitted by hand-genital contact.

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“…Such non-sexual routes of transmission include intrapartum transmission, inoculation from hand warts of either a child (autoinoculation) or parent, and intimate non-sexual contact (e.g., bathing with a relative who has genital warts). [36][37][38][39][40][41] In addition, non-penetrative sexual activity, such as handgenital or oral-genital contact, could also possibly transmit HPV although this has not been well studled.s…”

Section: Is Hpv Always Sexually Acquired?mentioning

confidence: 99%