DNA Supramolecular Hydrogel as a Biocompatible Artificial Vitreous Substitute

Jin, Yang; Li, Yujie; Song, Shengyuan; Ding, Yuqiao; Dong, Yuanchen; Li, Dongsheng; Zhang, Chun

doi:10.1002/admi.202101321

Cited by 20 publications

(10 citation statements)

References 51 publications

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“…From contact lenses, wound dressings, to drug delivery and tissue engineering, the resemblance to living tissue has enabled hydrogel a capable candidate for many biomedical applications. Physically or chemically cross-linked gels, [96] hydrogels made of natural or synthetic polymers, [97] chitosan gels, [98] DNA gels, [99][100][101][102][103][104] as well as stimuli-responsive ones, [105] various hydrogels have been developed. In principle, hydrogels are a 3D matrix composed of crosslinked hydrophilic polymers that can hold significant amounts of water.…”

Section: Hydrogelmentioning

confidence: 99%

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Wang

et al. 2023

Advanced Therapeutics

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Paclitaxel (PTX) is a broad-spectrum alkaloid anticancer drug with high therapeutic efficacy. However, PTX has a very low water solubility and its metabolism demonstrates nonlinear pharmacokinetic characteristics, resulting in systemic adverse reactions in clinical applications. Many endeavors are devoted to develop new PTX preparations in response to these obstacles, and some are used in clinical phase of cancer treatment. In particular, highly specific medical intervention at nanoscale is an emerging research field focusing on nanoapproaches to solve clinical problems. In a perspective of nanomedicine, the recent covalent and noncovalent approaches toward PTX formulation on various substrates, as well as their advantages and disadvantages during preclinical researches and clinical applications are herein summarized. It is anticipated that nanotechnology-based drug delivery systems can further enhance therapeutic efficiencies of PTX, by reducing systemic side effects and alleviating severely negative effects on patients.

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Section: Hydrogelmentioning

confidence: 99%

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Wang

et al. 2023

Advanced Therapeutics

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“…reported a DNA supramolecular network as a biocompatible artificial vitreous substitute, which was formed by the self‐assembly of rigid DNA units (Y shaped‐DNA and L shaped‐DNA). [ 35 ]…”

Section: Construction Of Polymeric Dna Networkmentioning

confidence: 99%

Construction of Polymeric DNA Network and Application for Cell Manipulation

et al. 2023

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Comprehensive Summary Deoxyribonucleic acid (DNA) is a biomacromolecule, as well as a polymeric material, whose sequences with different manipulative structures enable them to implement a series of functions, such as reorganization, target, and catalysis. Compared to existing traditional materials incapable of multifunctional integration, the polymeric DNA network is a form of material that can achieve functional integration while maintaining specific DNA properties. Furthermore, precise target enabled by DNA network is one of the most essential components of cellular manipulation. Hence, the DNA network is indispensable and irreplaceable to cell manipulation that it is a versatile tool for the understanding of basic laws of living life and treatments of diseases, such as cell isolation, cell delivery, and cell interference. Herein, the construction of polymeric DNA network is briefly introduced from the aspects of assembly modules, construction methods, and properties. Subsequently, the applications of DNA network in the field of cell manipulation, including cell isolation and encapsulation, intracellular inference and detection, and tumor therapy are summarized. Finally, we provide some prospects for further research and applications of DNA network for cell manipulation.

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“…Compared to the free hyaluronic acid solution, the supramolecular hyaluronic acid hydrogel had prolonged residence time on the cornea without complication [71]. In similar points of view but with different materials, the design architecture has included supramolecular hydrogels DNA-based which could form gel under physiological conditions and bring a promising candidate for vitreous substitute because is colorless and transparent, with a similar density to that of natural vitreous [72].…”

Section: Ophthalmic Hydrogelsmentioning

confidence: 99%

Structural Strategies of Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Preprint

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. These fields of scientific action include promising applications i biomedical areas, in sensing, and in conductive and electrical phases. The sensible definition of supramolecular molecules is being set by investigators, who, because of the different sensitivities of their methods and observational timescales, may have different views as to what constitute these supramolecular structures. Besides, diverse polymers can be found to offer unique avenues for multifunctional systems with properties in medicine industrial applications. Aspects of this review provide different conceptual strategies to address molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. In this order of appreciations and ideas order, it is that this review report involves classic topics such as hydrogels that range from their relationship with drug delivery systems, to metallo-supramolecular materials, through applications in ophthalmic systems, in applications that require adhesiveness and electrically conductive hydrogels. This review also addresses systems that are largely based on hydrogel chemistry and the enormous opportunities to design very specific structures for applications that demand enormous specificity.

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DNA Supramolecular Hydrogel as a Biocompatible Artificial Vitreous Substitute

Cited by 20 publications

References 51 publications

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Recent Progress of Paclitaxel Delivery Systems: Covalent and Noncovalent Approaches

Construction of Polymeric DNA Network and Application for Cell Manipulation

Structural Strategies of Supramolecular Hydrogels and Their Applications

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