DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeats
Nicholas J. Pederson,
Katharine L. Diehl
Abstract:Sirtuins are the NAD+-dependent class III lysine deacylases (KDACs). Members of this family have been linked to longevity and a wide array of different diseases, motivating the pursuit of sirtuin modulator compounds. Sirtuin 6 (SIRT6) is a primarily nuclear KDAC that deacetylates histones to facilitate gene repression. In addition to this canonical post-translational modification (PTM) “eraser” function, SIRT6 can use NAD+instead to “write” mono-ADP-ribosylation (mARylation) on target proteins. This enzymatic … Show more
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