1996
DOI: 10.1016/0047-6374(96)01738-1
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DNA status in brain and heart as prominent co-determinant for life span? Assessing the different degrees of DNA damage, damage susceptibility, and repair capability in different organs of young and old mice

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Cited by 16 publications
(5 citation statements)
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“…À and H 2 O 2 ) and DNA damage (measured in the form of nmol MDA equivalents/mg DNA) in the older over the younger participants (Table 2) (5) in the present study indicates that the old people were more susceptible to oxidative stress (41), and our results are consistent with the general definition of aging as the progressive accumulation of changes responsible for the decreased ability of the organism to maintain the homeostatic balance (1,7,31,(42)(43)(44)(45).…”
Section: Discussionsupporting
confidence: 89%
“…À and H 2 O 2 ) and DNA damage (measured in the form of nmol MDA equivalents/mg DNA) in the older over the younger participants (Table 2) (5) in the present study indicates that the old people were more susceptible to oxidative stress (41), and our results are consistent with the general definition of aging as the progressive accumulation of changes responsible for the decreased ability of the organism to maintain the homeostatic balance (1,7,31,(42)(43)(44)(45).…”
Section: Discussionsupporting
confidence: 89%
“…The mitochondrial OGG1 activity, however, was relatively lower in heart and muscle as well as in brain. Because heart and brain are postmitotic tissues, it has been postulated that accumulation of DNA damage in these tissues is a critical determinant for life span (33). Higher levels of 8‐oxodG were detected in rat brains than other tissues such as kidney and lung (34), and these have been shown to increase significantly with age in heart and brain (18).…”
Section: Discussionmentioning
confidence: 99%
“…Other investigators have also observed that cells or tissues from old animals are more sensitive to oxidative stress in vitro than cells or tissues from young animals. For example, Zahn et al (37) reported that DNA damage (strand breaks) induced after incubating tissues (liver, heart, brain, kidney, lung, skeletal muscle, and intestine) with nitroquinolin-N-oxide in vitro was 2-fold greater for tissues from old mice compared with tissues from young mice. Guo et al (36) found that more DNA damage (cyclobutane pyrimidine dimers) was induced by UV-irradiation in the nDNA of primary cultures of hepatocytes isolated from old rats compared with hepatocytes isolated from young rats.…”
Section: Discussionmentioning
confidence: 99%