DNA sequence analysis of the gene encoding the HTLV-I P21E transmembrane protein reveals inter- and intraisolate genetic heterogeneity

Ehrlich, Garth D.; Andrews, Janice M.; Sherman, Michael P.; Greenberg, Steven J.; Poiesz, Bernard J.

doi:10.1016/0042-6822(92)90028-n

Cited by 44 publications

(17 citation statements)

References 40 publications

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“…This may be due to the small number of available sequences and/or limited genetic variation. Some authors performed phylogenetic analyses with sequences of the BLV pol gene and HTLV-1 p21e gene, which proved inadequate to distinguish between viral strains [48,49]. The genetic variation of Primate T Leukemia Virus 1 (PTLV-1) in the env gene was greater than that of HTLV-II and BLV [50].…”

Section: Molecular Characterizationmentioning

confidence: 98%

Molecular characterization of the env gene from Brazilian field isolates of Bovine Leukemia Virus

Camargos¹,

Pereda

Stancek

et al. 2007

Virus Genes

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Molecular characterization of Bovine leukemia virus (BLV) isolates from Brazil using the env gene sequences revealed a high conservation of this gene. In most cases the substitutions corresponded to silent transitions. In addition, cystein residues, potential glycosylation sites, neutralization domains and other critical residues involved with the envelope structural domains and viral infectivity were conserved. Most of the substitutions found in the aminoacid sequences of the gp51 protein were localized in the G and H epitopes. Using the SIFT software, it was predicted that they should not alter the protein functions. Phylogenetic analyses showed that partial or complete env gene sequences grouped in three or four phylogenetic clusters, respectively. The sequences from the Brazilian isolates had similar mutation rates as compared to samples from other countries, and belonged to at least two phylogenetic clusters.

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Section: Molecular Characterizationmentioning

confidence: 98%

Molecular characterization of the env gene from Brazilian field isolates of Bovine Leukemia Virus

Camargos¹,

Pereda

Stancek

et al. 2007

Virus Genes

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“…The low variability of HTLV-I proviral sequence limits the use of molecular typing as proof of sexual or vertical transmission between epidemiological linked individuals. Neither is the occurrence of the HTLV-I diseases ATL and HAM/ TSP associated with the HTLV-I subtype of the infected human (Ehrlich et al, 1992;Gessain et al, 1992).…”

Section: Phylogeny and Molecular Epidemiologymentioning

confidence: 99%

Global epidemiology of HTLV-I infection and associated diseases

et al. 2005

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“…1). Phylogeny and molecular epidemiology studies have been used to explain this behavior of the infection (24).…”

Section: Geographic Distributionmentioning

confidence: 99%

“…Diverse studies have been performed on HTLV-1 subtyping but present a minor role in the epidemiological status of the virus. The great majority of infections are caused by the cosmopolitan subtype A, and there is no report of subtype influence on the pathogenic potential of HTLV-1 (24).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, Treatment, and Prevention of Human T-Cell Leukemia Virus Type 1-Associated Diseases

Gonçalves

Proietti

Ribas³

et al. 2010

Clin Microbiol Rev

400

321

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SUMMARYHuman T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus to be discovered, is present in diverse regions of the world, where its infection is usually neglected in health care settings and by public health authorities. Since it is usually asymptomatic in the beginning of the infection and disease typically manifests later in life, silent transmission occurs, which is associated with sexual relations, breastfeeding, and blood transfusions. There are no prospects of vaccines, and screening of blood banks and in prenatal care settings is not universal. Therefore, its transmission is active in many areas such as parts of Africa, South and Central America, the Caribbean region, Asia, and Melanesia. It causes serious diseases in humans, including adult T-cell leukemia/lymphoma (ATL) and an incapacitating neurological disease (HTLV-associated myelopathy/tropical spastic paraparesis [HAM/TSP]) besides other afflictions such as uveitis, rheumatic syndromes, and predisposition to helminthic and bacterial infections, among others. These diseases are not curable as yet, and current treatments as well as new perspectives are discussed in the present review.

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DNA sequence analysis of the gene encoding the HTLV-I P21E transmembrane protein reveals inter- and intraisolate genetic heterogeneity

Cited by 44 publications

References 40 publications

Molecular characterization of the env gene from Brazilian field isolates of Bovine Leukemia Virus

Molecular characterization of the env gene from Brazilian field isolates of Bovine Leukemia Virus

Global epidemiology of HTLV-I infection and associated diseases

Epidemiology, Treatment, and Prevention of Human T-Cell Leukemia Virus Type 1-Associated Diseases

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