DNA replication studies of human D-group chromosomes in satellite associations

Nakagome, Yasuo

doi:10.1159/000130040

Cited by 31 publications

(11 citation statements)

References 9 publications

(10 reference statements)

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“…As shown in earlier studies (Nakagome, 1969;Shaw et al, 1969), and as confirmed by the present study on 2 cases with t(13ql4q), satellite association is generally random. However, in some specific instances it may be non-random, as suggested by our 2 cases with t(l4qGq).…”

supporting

confidence: 91%

“…Further, an increased incidence of satellite association has been observed in families with translocation and multiple cases of mosaicism (Zeliweger, Abbo, and Cuany, 1966; Abbo, Zeliweger, and Cuany, 1966).Recently, Nakagome (1969) and Shaw, Craig, and Ricciuti (1969) showed that, in normal subjects, the members of the three pairs of D group chromosomes were randomly involved in satellite associations. However, these findings do not preclude the possibility that there are non-random patterns of associations in people who are 'predisposed' to translocation or non-disjunction.…”

mentioning

confidence: 98%

“…Recently, Nakagome (1969) and Shaw, Craig, and Ricciuti (1969) showed that, in normal subjects, the members of the three pairs of D group chromosomes were randomly involved in satellite associations. However, these findings do not preclude the possibility that there are non-random patterns of associations in people who are 'predisposed' to translocation or non-disjunction.…”

mentioning

confidence: 99%

“…The criteria for satellite association were either the presence of visible connexions between satellited ends of acrocentrics or the presence of acrocentrics within a distance of one chromatid width of each other, with orientation towards a common point by the satellited ends. (Yunis et al, 1964;Dekaban, 1966;Giannelli and Howlett, 1966;Rowley et al, 1967;Bloom and Gerald, 1967;Krmpotic, Ramanathan, and Grossman, 1968;Kohno and Makino, 1969;Palmer, Conneally, and Christian, 1969;Nakagome, 1969). There have been only 3 cases with other combinations (Giannelli, 1965;Higurashi et al, 1967;Lucas, 1969).…”

mentioning

confidence: 99%

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Satellite associations of D group chromosomes in translocation carriers.

Nakagome¹,

Bloom²

1970

Journal of Medical Genetics

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Satellite association has been postulated to increase the risk of either non-disjunction or translocation between acrocentric chromosomes (FergusonSmith and Handmaker, 1961;Ohno et al., 1961;Ferguson-Smith, 1964). Further, an increased incidence of satellite association has been observed in families with translocation and multiple cases of mosaicism (Zeliweger, Abbo, and Cuany, 1966; Abbo, Zeliweger, and Cuany, 1966).Recently, Nakagome (1969) and Shaw, Craig, and Ricciuti (1969) showed that, in normal subjects, the members of the three pairs of D group chromosomes were randomly involved in satellite associations. However, these findings do not preclude the possibility that there are non-random patterns of associations in people who are 'predisposed' to translocation or non-disjunction. Materials and MethodsTwo carriers with t(l4qGq) from one family and two carriers with t(13ql4q) from another family were studied.Both translocations were of the centric-fusion type.The peripheral blood culture and autoradiography techniques used are described elsewhere (Nakagome, 1969). During the last five hours of the standard leucocyte culture (72 hours), cells were treated with 3H-thymidine. The final concentration was 0 5 tuCi/ml. and the specific activity was 2Ci/mmole. The criteria for satellite association were either the presence of visible connexions between satellited ends of acrocentrics or the presence of acrocentrics within a distance of one chromatid width of each other, with orientation towards a common point by the satellited ends.

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supporting

confidence: 91%

mentioning

confidence: 98%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Satellite associations of D group chromosomes in translocation carriers.

Nakagome¹,

Bloom²

1970

Journal of Medical Genetics

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“…These examples suggest that, in spite of a frequent NOR (satellite) association (Nakagome, 1969;van Hemel, 1971), Rabl configuration (Cremer et al, 1982), telomere-telomere attachment (Sved, 1966;Ashley and Pocock, 1981), or the so-called bouquet configuration, telomeres are usually protected safely from chromosomal rearrangements. However, telomeric fusions occur often under some specific conditions such as long-term cell culture, tumoriogenesis, or infection by virus/transposon like or unknown factors other than ionizing radiation.…”

Section: ) a Possible Biological Significance Of The Fusion Burst Inmentioning

confidence: 99%

Theoretical bases for karyotype evolution. II. The fusion burst in man and mouse.

Imai

Takahata

Maruyama

et al. 1988

The Japanese journal of genetics

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As a theoretical standard for evaluating the high incidence of centric fusion in man and mouse, the relative probabilities of occurrence of reciprocal translocation (Tr), inversion (In) and centric fusion (Fu) were estimated based on the randomcontact-and-exchange model. It was shown by this model that centric fusion was extremely rare (Fu=0.0002, In=0.0521 and Tr=0.9477 for a human haploid karyotype).On the other hand, the occurrence rate of centric fusion in human newborn babies and European feral mice was about 500-1,000 times higher than the theoretically expected values, which is termed here the "fusion burst". We suggest that the fusion burst may be induced by the physical proximity of telomeres on the nuclear membrane, and the exchange of DNA strands by errors of telomere replication mechanisms.The cytogenetical significance of the fusion burst is discussed with regard to the minimum interaction hypothesis proposed by Imai et al. (1986). We suggest two closely linked possibilities that (1) the fusion burst in man and mouse can theoretically be placed in karyotype evolution as a transitional phase in the main stream of the fission-inversion cycle, and (2) it may be accelerated by some unknown (mutagenic) factors other than ionizing radiation.

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