DNA repair systems as targets of cadmium toxicity

Giaginis, Constantinos; Gatzidou, Elisavet; Theocharis, Stamatios

doi:10.1016/j.taap.2006.03.008

Cited by 207 publications

(148 citation statements)

References 58 publications

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“…These pro-oxidant effects of Cd may augment reoxygenation-induced ROS production and explain mitochondrial deterioration and oxidative DNA damage observed during combined exposure to Cd and anoxia-reoxygenation stress in this study. Another possible explanation for the higher frequency of DNA lesions in Cd-exposed oysters is inhibition of DNA repair machinery by Cd (15,25). Specifically, apurinic/apyrimidinic (AP) endonuclease 1, which initiates repair of AP lesions by incising the DNA backbone, is inhibited by Cd 2ϩ at high concentrations (Ͼ10 M) (50).…”

Section: Discussionmentioning

confidence: 99%

Cadmium affects metabolic responses to prolonged anoxia and reoxygenation in eastern oysters (Crassostrea virginica)

Kurochkin

Ivanina

Eilers

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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Kurochkin IO, Ivanina AV, Eilers S, Downs CA, May LA, Sokolova IM. Cadmium affects metabolic responses to prolonged anoxia and reoxygenation in eastern oysters (Crassostrea virginica). Am J Physiol Regul Integr Comp Physiol 297: R1262-R1272, 2009. First published September 2, 2009 doi:10.1152/ajpregu.00324.2009.-Benthic marine organisms such as mollusks are often exposed to periodic oxygen deficiency (due to the tidal exposure and/or seasonal expansion of the oxygen-deficient dead zones) and pollution by metals [e.g., cadmium, (Cd)]. These stressors can strongly affect mollusks' survival; however, physiological mechanisms of their combined effects are not fully understood. We studied the effects of Cd exposure on metabolic responses to prolonged anoxia and subsequent recovery in anoxia-tolerant intertidal mollusks Crassostrea virginica (eastern oysters). Anoxia led to an onset of anaerobiosis indicated by accumulation of L-alanine, acetate, and succinate. Prolonged anoxia (for 6 days) caused a decline in the maximum activity of electron transport chain and ADP-stimulated (state 3) oxygen uptake by mitochondria (MO 2), but no change in the resting (state 4) MO 2 of oyster mitochondria, along with a slight but significant reduction of mitochondrial respiratory control ratio. During reoxygenation, there was a significant overshoot of mitochondrial MO 2 (by up to 70% above the normoxic steady-state values) in control oysters. Mild mitochondrial uncoupling during prolonged shutdown in anoxic tissues and a subsequent strong stimulation of mitochondrial flux during recovery may help to rapidly restore redox status and protect against elevated reactive oxygen species formation in oysters. Exposure to Cd inhibits anaerobic metabolism, abolishes reoxygenation-induced stimulation of mitochondrial MO 2, and leads to oxidative stress (indicated by accumulation of DNA lesions) and a loss of mitochondrial capacity during postanoxic recovery. This may result in increased sensitivity to intermittent hypoxia and anoxia in Cd-exposed mollusks and will have implications for their survival in polluted estuaries and coastal zones. air exposure; recovery; mitochondrial function; oxidative damage; mollusks PERIODICAL OXYGEN DEFICIENCY is an important environmental stressor in intertidal and coastal habitats. Short-term intermittent hypoxia/anoxia (from several hours to several days, depending on the state of the tides) often occurs in intertidal invertebrates during the low tide, and may also occur in tidal pools and shallow lagoons with limited water exchange (8,36,49). Furthermore, long-term severe hypoxia and anoxia triggered by anthropogenic release of nutrients has become a serious issue in many estuaries and coastal zones rivaling the climate change (18,22). In the coastal dead zones, benthic invertebrates including mollusks can be exposed to severe hypoxia or anoxia for prolonged periods (from weeks to up to several months) (10,22,34,46). Long-term oxygen deficiency often leads to the massive die-offs in species with limited or...

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Section: Discussionmentioning

confidence: 99%

Cadmium affects metabolic responses to prolonged anoxia and reoxygenation in eastern oysters (Crassostrea virginica)

Kurochkin

Ivanina

Eilers

et al. 2009

American Journal of Physiology-Regulatory, Integrative and Comp

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“…156,157 Cd(II) is highly toxic at low concentrations and can accumulate in living organisms by smoking cigarettes, eating contaminated food, and drinking contaminated water. [157][158][159] Surface imprinting technology with support particles like silica gel is a common design for the synthesis of Cd-IIPs. 157,160,161 Based on a sol-gel technique combining with a doubleimprinting concept, Hu et al 162 prepared a Cd(II) imprinted 3-mercaptopropyltrimethoxysilane (MPTS)-silica coated stir bar for selective stir bar sorptive extraction (SBSE) of trace Cd(II) from environmental water samples via ICP-MS detection.…”

Section: Tablementioning

confidence: 99%

Current status and challenges of ion imprinting

et al. 2015

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Ion imprinting technology (IIT) aims to recognize ions while retaining the unique virtues of molecular imprinting technology (MIT), namely structure predictability, recognition specificity and application universality. Owing to special coordination or electrostatic interactions, ion imprinted polymers (IIPs) are generally compatible with aqueous media and have advantages over most molecularly imprinted polymers (MIPs). IIPs can achieve effective identification of water-soluble ions, especially heavy metals and radioactive elements that cause increasing concerns. The purpose of this review is to summarize recent advances of ion imprinting, focusing on the current status and challenges in fundamentals and applications that involve almost all types of ions and ion-related molecular imprinting. In addition, various smart strategies are highlighted, such as surface imprinting, stimuli-responsive imprinting, dual/ multiple components imprinting, click chemistry, and microwave-assisted heating. In this review, the elemental periodic table is first utilized as a template to introduce ion classification standards for various IIPs, including main groups, transition elements, actinides, rare earths, metalloids, anion imprinting and secondary imprinting. Finally, the challenges and possible solution strategies plus future trends are also proposed (302 references).

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“…In spite of being a weak genotoxic chemical, cadmium exhibits remarkable potential to inhibit DNA damage repair, and this has been identified as a major mechanism for its carcinogenicity (Giaginis et al, 2006). Cadmium is comutagenic and increases the mutagenicity of UV radiaton, alkylation and oxidation in mammalian cells.…”

Section: Cadmiummentioning

confidence: 99%