DNA Repair Molecules and Cancer Therapeutical Responses

Kobayashi, Masaru; Matsuda, Satoru

doi:10.5772/53532

Cited by 1 publication

(1 citation statement)

References 49 publications

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“…Moreover, in MCF7 cells in which oestrogen receptor is activated, DNA damage inhibited checkpoint cell cycle, which resulted in less effective DNA repair. In the cancer cells, where oestrogen receptor is inhibited, there was a better DNA repair and improved cell survival, which decreased the cytotoxic action of cisplatin 26 . BRCA1 has been proved to interact physically with ER-α and inhibit its transcriptional activity.…”

Section: Discussionmentioning

confidence: 99%

A new hexapeptide from the leader peptide of rMnSOD enters cells through the oestrogen receptor to deliver therapeutic molecules

Borrelli

Schiattarella²,

Mancini

et al. 2016

Sci Rep

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A 24-amino acid leader peptide of a new human recombinant manganese superoxide dismutase can enter cells and carry molecules. Here, we demonstrated that six of the 24 amino acids penetrate cells through a particular gate represented by a specific amino acid sequence of the oestrogen receptor (ER). We analysed the internalization of the synthetic hexapeptide and the cytotoxic activity of the hexapeptide conjugated to cisplatin on a cell line panel. In most cell lines, the hexapeptide delivered an amount of cisplatin that was 2 to 8 times greater than that released by cisplatin when the drug was used alone. This increased delivery increases the therapeutic index of cisplatin and reduces side effects caused by a high dosage or long-term treatment times. We may consider this hexapeptide a new molecular carrier to deliver molecules with therapeutic activity into ER+ cells for diagnostic purposes and clinical or immune therapy.

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Section: Discussionmentioning

confidence: 99%