DNA Repair: Lessons from the Evolution of Ionizing- Radiation-Resistant Prokaryotes – Fact and Theory

Sghaier, Haïtham

doi:10.5772/22312

Cited by 3 publications

(2 citation statements)

References 90 publications

(96 reference statements)

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“…Radiation-resistant (Rr) and desiccation-resistant (Dr) bacteria can survive with exposure to radiation and desiccation cycles in natural habitats. Their resistance capabilities were confirmed during laboratory experimentation (Singh and Gabani, 2011;Paulino-Lima et al, 2013), while the radiosensitive bacterial cells immediately reduced in number with radiation exposure (Sghaier, 2011). Based on the wavelength, electromagnetic radiation comprises ionizing radiation (IR) and non-IR.…”

Section: Introductionmentioning

confidence: 88%

Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences

Khan,

Liu,

Zhang

et al. 2024

Front. Microbiol.

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A rich diversity of radiation-resistant (Rr) and desiccation-resistant (Dr) bacteria has been found in arid habitats of the world. Evidence from scientific research has linked their origin to reactive oxygen species (ROS) intermediates. Rr and Dr. bacteria of arid regions have the potential to regulate imbalance radicals and evade a higher dose of radiation and oxidation than bacterial species of non-arid regions. Photochemical-activated ROS in Rr bacteria is run through photo-induction of electron transfer. A hypothetical model of the biogeochemical cycle based on solar radiation and desiccation. These selective stresses generate oxidative radicals for a short span with strong reactivity and toxic effects. Desert-inhibiting Rr bacteria efficiently evade ROS toxicity with an evolved antioxidant system and other defensive pathways. The imbalanced radicals in physiological disorders, cancer, and lung diseases could be neutralized by a self-sustaining evolved Rr bacteria antioxidant system. The direct link of evolved antioxidant system with intermediate ROS and indirect influence of radiation and desiccation provide useful insight into richness, ecological diversity, and origin of Rr bacteria capabilities. The distinguishing features of Rr bacteria in deserts present a fertile research area with promising applications in the pharmaceutical industry, genetic engineering, biological therapy, biological transformation, bioremediation, industrial biotechnology, and astrobiology.

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Section: Introductionmentioning

confidence: 88%

Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences

Khan,

Liu,

Zhang

et al. 2024

Front. Microbiol.

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“…To be considered as an RP, a microorganism should have a D 10 -the ionizing-radiation (IR) dose necessary to effect a 90 % reduction in colony-forming units (CFU)-threshold that is greater than 1 kilogray (kGy), corresponding to efficient physiological, genetic and proteic protection and repair mechanisms ( [1,2] and references therein). In this context, to our knowledge, even when prokaryotic members belonging to a radioresistant-species-harbouring genus have contrasted optimum temperatures-for example, ranging from 10 to 47 ºC-the least IR-resistant ones do not have D 10 values inferior to 1 kGy [3].…”

Section: Introductionmentioning

confidence: 99%

The RadioP1 – An Integrative Web Resource for Radioresistant Prokaryotes

Hamda¹,

Benkahla²,

Ben-Miled³

et al. 2015

Evolution of Ionizing Radiation Research

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The extremely radioresistant eubacterium Deinococcus radiodurans and the phenotypically related prokaryotes, whose genomes have been completely sequenced, are presently used as model species in several laboratories to study the lethal effects of DN"-damaging and protein-oxidizing agents, particularly the effects of ionizing radiation IR . Unfortunately, providing relevant information about radioresistant prokaryotes RP in a neatly centralized and organized manner still remains a need. In this study, we designed RadioP Web resource www.radiop.org.tn to gather information about RP defined by the published literature with specific emphasis on i predicted genes that produce and protect against oxidative stress, ii predicted proteins involved in DN" repair mechanisms and iii potential uses of RP in biotechnology. RadioP allows the complete RP proteogenomes to be queried using various patterns in a user-friendly and interactive manner. The output data can be saved in plain text, Excel or HyperText Markup Language HTML formats for subsequent analyses. Moreover, RadioP provides for users a tool ST"RT "N"LY-SIS , including the previously described R-packages drc and lethal , to generate exponential or sigmoid survival curves with D and D values. Furthermore, when accessible, links to external databases are provided. Supplementary data will be included in the future when the sequences of other RP genomes will become available.

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Exobiology of the Venusian Clouds: New Insights into Habitability through Terrestrial Models and Methods of Detection

et al. 2021

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DNA Repair: Lessons from the Evolution of Ionizing- Radiation-Resistant Prokaryotes – Fact and Theory

Cited by 3 publications

References 90 publications

Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences

Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences

The RadioP1 – An Integrative Web Resource for Radioresistant Prokaryotes

Exobiology of the Venusian Clouds: New Insights into Habitability through Terrestrial Models and Methods of Detection

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