DNA Repair in Relation to the Aging Process

Vijg, Jan; Knook, D.L.

doi:10.1111/j.1532-5415.1987.tb01400.x

Cited by 37 publications

(5 citation statements)

References 35 publications

(38 reference statements)

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“…Thus, it is not surprising that DNA damage and repair is an important feature of several theories on aging (Vijg and Knook 1987;Kirkwood 1989). An early indication that the aging process may be related to the efficiency of DNA repair was the highly significant correlation observed between maximum species lifespan and the level of unscheduled DNA synthesis induced by ultraviolet light in fibroblast cells obtained from representative mammals (Tice and Setlow 1985).…”

Section: Discussionmentioning

confidence: 97%

The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations

et al. 2007

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In the present study, we used the Comet assay to estimate basal DNA damage in three distinct populations aged 5-10, 40-50, and 60-70 years old. The DNA damage induced by hydrogen peroxide and gamma-irradiation in the lymphocytes of these populations, as well as their repair activity, was also studied. Finally, we measured apoptosis and necrosis after the effect of these agents. Our results indicate that the older population (60-70 years old) showed higher basal levels of DNA damage and was more sensitive to the effects of the DNA-damaging agents than the adult one (40-50 years old), who, in turn, was more sensitive than the younger population (5-10 years old). A decline of the repair efficiency with age to the DNA damage induced by the two agents was also observed. Apoptosis and necrosis were also affected by age.

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Section: Discussionmentioning

confidence: 97%

The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations

et al. 2007

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“…These findings, however, are not confirmed in leukocytes 46 . The DNA repair ability as measured by “unscheduled” DNA synthesis that occurs after irradiation or ultraviolet light exposure has been found to be either unaltered or decreased with age 47–49 . It is noteworthy, however, that the decline in DNA repair capacity occurs after the development of senescent features in cells, and, therefore, its primary role in cellular senescence is questionable.…”

Section: Age‐related Changes In Proteinsmentioning

confidence: 94%

Molecular Biology of Aging Part II: A Synopsis of Current Research

Mooradian

Wong

1991

J American Geriatrics Society

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“…31 Furthermore, DNA repair is less efficient in cells from ageing individuals or senescent cultures. 32 Werner's syndrome is a disorder associated with premature ageing in certain systems. The defective gene has now been identified and its product resembles helicase which is required for DNA repair.…”

Section: The Role Of Repairmentioning

confidence: 99%

The ageing process

Sayer

Cooper

2000

British Menopause Society Journal

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Average life expectancy at birth has risen from 42 to 78 in the last 150 years. 6 This is partly due to decreasing neonatal and infant mortality, but life expectancy in middle age is also rising -in contrast with maximum lifespan, which has probably only doubled since man evolved. 7,8 So while it has been argued mathematically that there is no evidence for a finite human lifespan, it seems likely that the potential for modifying the rate of ageing is greater than that for avoiding it altogether. 9 The existence of wide variability in ageing between individuals supports this idea. 10 The development of effective anti-ageing interventions, however, requires understanding of the underlying processes and how they may be influenced.In this review we discuss some of the complexities involved in understanding ageing, including the wide range of theories. The genetic contribution is considered together with the role of random events. There is growing support for the importance of repair processes and evidence for this is presented. The final section addresses the potential for modification of the ageing process and describes recent developments. SummaryAgeing may be simply defined but is yet to be well understood. Research in this area is considered a priority, with the population growing older and increasing disability, morbidity and mortality predicted. There are many theories and ageing has been described from changes at the molecular level to characteristics of ageing populations. However, distinguishing cause from effect has proved problematic largely because the underlying reasons for ageing have not been understood. Progress has now been made and the central role for repair processes is increasingly accepted. A number of approaches to modifying ageing have been explored but the only reliable method to alter the rate remains diet restriction. Instituted after weaning, diet restriction slows ageing in a number of species and has an opposite effect when started in earlier life. There is now preliminary evidence that poor early growth is associated with increased human ageing and this is an important area for future research. Downloaded from prerequisites are incorporated: a careful consideration of an appropriate comparator, discounting and a sensitivity analysis.

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DNA Repair in Relation to the Aging Process

Cited by 37 publications

References 35 publications

The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations

The use of comet assay in measuring DNA damage and repair efficiency in child, adult, and old age populations

Molecular Biology of Aging Part II: A Synopsis of Current Research

The ageing process

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