DNA Repair Genes<i>XRCC1</i>and<i>ERCC1</i>Polymorphisms and the Risk of Sporadic Breast Cancer in Han Women in the Gansu Province of China

Zhu, Guanbao; Wang, Lan; Guo, Hongyun; Lu, Lingeng; Yang, Sheng; Wang, Tao; Guo, Huimin; Wang, Haitao; Min, Jianping; Yang, Kai; Chen, Xuezhong; Yuan-qiang, Liu; Wang, Zhiping; Su, Hongling

doi:10.1089/gtmb.2015.0001

Cited by 9 publications

(11 citation statements)

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“…Taken together, the current results did not suggest that the XRCC1 gene polymorphism plays a significant role in the initiation of BC. Similar to the current findings, previous investigations did not show an association between the ERCC1 (rs3212964) gene polymorphism and the risk of BC (15,28). Furthermore, ASE-1 has been found in an antisense orientation and overlaps with the ERCC1 gene and is likely involved with RNA polymerase I transcription complex.…”

Section: Discussionsupporting

confidence: 88%

“…During the DNA base pair repair procedure, the XRCC1 gene was implicated in the change of DNA damages and single-strand DNA disputes through DNA ligase III enzyme, at its carboxyl and DNA polymerase beta and poly ADPRibose polymerase at the site of the damaged DNA (15,19). The XRCC1 function is needed for DNA repair and genome integrity (20).…”

Section: Discussionmentioning

confidence: 99%

“…Preliminary investigations have shown several SNPs in the XRCC1 and ERCC1 genes involved in tumorigenesis. According to previous considerations, findings have revealed contradictory results regarding several diseases and different ethnic geographical regions (15)(16)(17). To provide greater insight regarding the association between particular SNPs in the XRCC1 and ERCC1 genes in the tumorigenesis of BC, this study aimed at evaluating the associated between XRCC1 (rs25487) and ERCC1 (rs3212964) gene polymorphisms and the risk of sporadic BC in females of the northwestern of …”

Section: Introductionmentioning

confidence: 99%

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Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

et al. 2018

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Background: Recently, findings have validated the significant role of DNA damage genes related to the pathogenesis of breast cancer (BC). The aim of the present investigation was to evaluate possibility roles of two common XRCC1 (rs25487; A > G) and ERCC1 (rs3212964; A > G) gene polymorphisms with the risk of sporadic BC. Methods: This was a case-control study, consisting of 100 females identified with sporadic BC and 100 malignancy-free females as the control group. This study used Tetra-ARMS Polymerase Chain Reaction (PCR) and PCR-Restriction Fragment Length Polymorphism (RFLP) methods to determine genotype frequencies of XRCC1 and ERCC1 genes. Results: The findings did not reveal a statistically significant difference in the genotype frequencies of XRCC1 and ERCC1 genes between the two groups (P > 0.05). The frequency of G mutant allele for XRCC1 and ERCC genes was higher in cases compared to controls, while the difference between the groups was not statistically significant (P = 0.202; OR: 1.312; CI: 0864 -1.994), (P = 0.352; OR: 1.213; CI: 0.808 -1.820). Conclusions:The current results provide evidence against the hypothesis that XRCC1 (rs25487) and ERCC1 (rs3212964) gene polymorphisms may be associated with a predisposition to sporadic BC.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

et al. 2018

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“…Deviations of observed genotype frequencies of SNPs were tested for Hardy-Weinberg equilibrium (HWE). Associations between nineteen SNPs and bladder cancer risk were estimated by odds ratios (ORs) and their 95% confidence intervals (CIs) using unconditional logistic regression with adjustment for age, gender, smoking and drinking status in different genetic models (codominant, dominant, recessive, and additive models) as previously described [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in Gansu province of China

Zhu

Su²,

et al. 2016

Oncotarget

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BackgroundBalance of DNA damage and proper repair plays an important role in progression of bladder cancer. Here we aimed to assess the associations of nineteen polymorphisms from seven DNA repair–associated genes (PRAP1, OGG1, APEX1, MUTYH, XRCC1, XRCC2 and XRCC3) with bladder cancer and their interactions in the disease in a Han Chinese population.Methodology/Principal FindingsA chip-based TaqMan genotyping for the candidate genes was performed on 227 bladder cancer patients and 260 healthy controls. APEX1 rs3136817, MUTYH rs3219493, three SNPs (rs3213356, rs25487 and rs1799782) in XRCC1, and three SNPs (rs1799794, rs861531 and rs861530) in XRCC3 showed significant associations with the risk of bladder cancer. In haplotype analysis, elevated risks of bladder cancer were observed in those with either haplotype GT (OR = 1.56, P = 0.003) of APEX1, or GGGTC (OR = 2.05, P = 0.002) of XRCC1, whereas decreased risks were in individuals with either GCGCC (OR = 0.40, P = 0.001), or GCGTT (OR = 0.60, = 0.005) of XRCC1, or CCC (OR = 0.65, P = 0.004) of MUTYH, or TTTAT (OR = 0.36, P = 0.009) of XRCC3. Interaction analysis showed that the two-loci model (rs1799794 and rs861530) was the best with the maximal testing accuracy of 0.701, and the maximal 100% cross-validation consistency (P = 0.001).ConclusionsPolymorphisms and haplotypes of DNA repair genes are associated with the risk of bladder cancer, and of which the SNPs (rs1799794 and rs861530) in XRCC3 gene might be two major loci in relation to the susceptibility to bladder cancer in a northwest Chinese population.

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“…To date, there have been seven case–control studies devoted to shedding light on the link between the rs11615 polymorphism and breast cancer risk. The studies conducted by Yang et al [ 28 ], He et al [ 31 ], and Pongsavee et al [ 32 ] found that the rs11615 polymorphism was associated with an increased risk of breast cancer, while others drew the opposite conclusion [ 26 , 27 , 29 , 30 ]. Here, we looked for powerful evidence that either supports or refutes the validity of associations between the ERCC1 rs11615 polymorphism and breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

ERCC1 rs11615 polymorphism increases susceptibility to breast cancer: a meta-analysis of 4547 individuals

Shi

Yuan

et al. 2018

Bioscience Reports

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Excision repair cross-complementation group 1 (ERCC1), a DNA repair protein, is vital for maintaining genomic fidelity and integrity. Despite the fact that a mounting body of case–control studies has concentrated on investigating the association of the ERCC1 rs11615 polymorphism and breast cancer risk, there is still no consensus on it. We conducted the current meta-analysis of all eligible articles to reach a much more explicit conclusion on this ambiguous association. A total of seven studies involving 2354 breast cancer cases and 2193 controls were elaborately selected for this analysis from the Embase, EBSCO, PubMed, WanFang, and China National Knowledge Infrastructure (CNKI) databases. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated in our meta-analysis. We found that the ERCC1 rs11615 polymorphism was significantly associated with breast cancer risk under all genetic models. When excluded, the studies that deviated from Hardy–Weinberg equilibrium (HWE), the pooled results of what remained significantly increase the risk of breast cancer under the allele model (OR = 1.14, 95% CI = 1.02–1.27, P=0.02), heterozygote model (OR = 1.24, 95% CI = 1.06–1.44, P=0.007), and dominant model (OR = 1.21, 95% CI = 1.05–1.41, P=0.01). This increased breast cancer risk was found in Asian population as well as under the heterozygote model (OR = 1.24, 95% CI = 1.05–1.48, P=0.013) and dominant model (OR = 1.20, 95% CI = 1.02–1.42, P=0.03). Our results suggest that the ERCC1 rs11615 polymorphism is associated with breast cancer susceptibility, and in particular, this increased risk of breast cancer existence in Asian population.

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DNA Repair GenesXRCC1andERCC1Polymorphisms and the Risk of Sporadic Breast Cancer in Han Women in the Gansu Province of China

Abstract: The results suggest that the XRCC1 rs25487 polymorphism may increase the risk of breast cancer.

Cited by 9 publications

References 40 publications

Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

Association of Genetic Variations in XRCC1 and ERCC1 Genes with Sporadic Breast Cancer

Association of nineteen polymorphisms from seven DNA repair genes and the risk for bladder cancer in Gansu province of China

ERCC1 rs11615 polymorphism increases susceptibility to breast cancer: a meta-analysis of 4547 individuals

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