DNA repair efficiency associated with reprogrammed osteosarcoma cells

Choong, Philip Iau Tsau; Teh, H.; Teoh, Hoon Koon; Ong, Han-Kiat; Cheong, Soon-Keng; Kamarul, Tunku

doi:10.1016/j.genrep.2019.100409

Cited by 1 publication

(2 citation statements)

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“…Melanocyte-iPSC lines showed pluripotency markers and the ability to differentiate into embryoid bodies in vitro and teratoma formation after injection into the dorsal flank of mice in vivo [ 12 ]. There are some reports of cancer-iPSCs teratoma formation [ 13 – 15 , 25 ], pluripotency character [ 9 , 14 , 26 , 27 ], and differentiation capacity [ 26 ] (Fig. 1 ).…”

Section: Cancer-ipscs and Other Pscs: A Comparison Studymentioning

confidence: 99%

“…Malignant tumors are cancerous [ 40 ]. There are some reports of teratoma formation for cancer-iPSCs derived from Acute Myelogenous Leukemia Cells [ 13 ], breast cancer cells [ 14 ], prostate cancer cells [ 15 ], and osteosarcoma cells [ 25 ]. iPSCs can make teratomas quicker and more efficiently than ESCs in vivo, indicating their higher potency in making tumors [ 41 ].…”

Section: Cancer-ipscs and Other Pscs: A Comparison Studymentioning

confidence: 99%

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Cancer cells as a new source of induced pluripotent stem cells

et al. 2022

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Over the last 2 decades, induced pluripotent stem cells (iPSCs) have had various potential applications in various medical research areas, from personalized medicine to disease treatment. Different cellular resources are accessible for iPSC generation, such as keratinocytes, skin fibroblasts, and blood or urine cells. However, all these sources are somatic cells, and we must make several changes in a somatic cell’s transcriptome and chromatin state to become a pluripotent cell. It has recently been revealed that cancer cells can be a new source of iPSCs production. Cancer cells show similarities with iPSCs in self-renewal capacity, reprogramming potency, and signaling pathways. Although genetic abnormalities and potential tumor formation in cancer cells pose a severe risk, reprogrammed cancer-induced pluripotent stem cells (cancer-iPSCs) indicate that pluripotency can transiently overcome the cancer phenotype. This review discusses whether cancer cells can be a preferable source to generate iPSCs.

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