DNA repair and longevity in three species of cold-blooded vertebrates

Woodhead, Avril D.; Setlow, R. B.; Grist, E.

doi:10.1016/0531-5565(80)90034-0

Cited by 63 publications

(15 citation statements)

References 6 publications

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“…In cultured fish cells, dark repair (nucleotide excision repair, NER) has been suggested to proceed at a very slow rate relative to mammalian cells (Regan and Cook, 1967;Woodhead et al, 1980;Shima et al, 1981;Mano et al, 1982;Regan et al, 1982;Park and Li, 1989). In contrast, several reports indicate that fish cells possess robust photoenzymatic repair capabilities specific for both UV-induced pyrimidine dimers (PyP) and 6-4 photoproducts (6-4PD) (Yasuhira et al, 1992;Ahmed et al, 1993;Uchida et al, 1997Uchida et al, , 1998Meador et al, 2000;and Mitchell et al, this issue).…”

Section: Introductionmentioning

confidence: 88%

Relative Base Excision Repair in Xiphophorus Fish Tissue Extracts

Walter

Sung

Obermoeller

et al. 2001

Marine Biotechnology

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To begin characterizing DNA repair capability among Xiphophorus species, we adapted oligonucleotide-based DNA repair assays to extracts of fish tissues. Here, we report the initial results of relative base excision repair (BER) capability among 3 inbred Xiphophorus fish lines representing 2 species (X. maculatus and X. couchianus), and interspecies hybrid F(1) animals produced by crossing them. Overall, data from uracil- N-glycosylase (UNG)-initiated BER assay (UNG-BER) indicate that brain tissue extracts generally possess higher BER activity than do gill and liver extracts. UNG-BER activities in gill and liver extracts were similar. The BER activity in the tissues of F(1) interspecies hybrids followed the activity pattern of the X. couchianus parent in gill and liver extracts, was similar to the X. maculatus parent in brain extracts, but exhibited a reduced repair capacity in gill tissue extracts compared with either parent. We discuss the use of oligonucleotide-based DNA repair assays to elucidate the role that inheritance of DNA repair potential may play in susceptibility to disease and tumorigenesis in the intact organism.

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Section: Introductionmentioning

confidence: 88%

Relative Base Excision Repair in Xiphophorus Fish Tissue Extracts

Walter

Sung

Obermoeller

et al. 2001

Marine Biotechnology

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“…There are a few observations in long-lived counterparts which have an indeterminate life-span and are believed to show negligible senescence. Whether their extended longevity is due to less vulnerability to predation [5], continued proliferation and replacement of cells [138], developmental influences or other strategies associated with repair of damaging effects on macromolecules [139] is still unde cided and needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Ageing in Reptiles

Patnaik¹

1994

Gerontology

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Like in fishes, the reptiles appear to show three types of senescence. The African skink, Mabuya buettneri, shows rapid senescence similar to death at mating observed in Salmon and marsupial mouse. Most of the lizards and snakes undergo gradual senescence comparable to the pattern exhibited by a majority of vertebrates. On the other hand, turtles, tortoises and crocodiles continue to grow throughout life and are thus credited with slow or negligible senescence. Evidences and mechanisms of rapid or negligible senescence in reptiles are still fragmentary and unclear. Findings in a few species of lizards (Calotes versicolor) and snakes (Natrix natrix) showing gradual senescence support the concept of commonalities in ageing phenomena in vertebrates. An age-related increase in the stability of collagen and accumulation of altered enzyme molecules, a decrease in metabolism and response to stress-enhanced anti-oxidative defence mechanisms and the nature of responses to hormones, restricted diet and lower environmental temperature corroborate the concept. On the other hand neither the increase in mortality rate and accumulation of lipofuscin nor the reproductive senility have been shown conclusively in ageing reptile populations. It is likely that there are multiple mechanisms of senescence in reptiles. Further studies on selected species from among the 6,000 living species are necessary to unravel the phenomena.

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“…The first analysis of NER involving a small number of species, found a strong correlation between NER efficiency and MLS [54], while later studies with larger numbers of species failed to find such a relationship [55, 56]. DNA double-strand break recognition was found to correlate with species MLS, which may be attributable to higher abundance of Ku80 in longer-lived species [57].…”

Section: Dna Repair Machinerymentioning

confidence: 99%

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species

Tian

Seluanov

Gorbunova

2017

Trends in Endocrinology & Metabolism

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Aging is a global decline of physiological functions, leading to an increased susceptibility to diseases and ultimately death. Maximum lifespans differ up to 200-fold between mammalian species. Although considerable progress has been achieved in identifying conserved pathways that regulate individual lifespan within model organisms, whether the same pathways are responsible for the interspecies differences in longevity remains to be determined. Recent cross-species studies have begun to identify pathways responsible for interspecies differences in lifespan. Here, we review the evidence supporting the role of anti-cancer mechanisms, DNA repair machinery, insulin/IGF1 signaling, and proteostasis in defining species lifespans. Understanding the mechanisms responsible for the dramatic differences in lifespan between species will have a transformative effect on developing interventions to improve human health and longevity.

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DNA repair and longevity in three species of cold-blooded vertebrates

Cited by 63 publications

References 6 publications

Relative Base Excision Repair in Xiphophorus Fish Tissue Extracts

Relative Base Excision Repair in Xiphophorus Fish Tissue Extracts

Ageing in Reptiles

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species

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