DNA polymorphism analysis of candidate genes for type 2 diabetes mellitus in a Mexican ethnic group

Flores-Martínez, Silvia Esperanza; Islas-Andrade, Sergio; Machorro-Lazo, Maria-Victoria; Revilla, M.C.; Juárez, R.E.; Mújica‐López, K. I.; Morán-Moguel, María Cristina; López-Cardona, María Guadalupe; Sánchez‐Corona, José

doi:10.1016/j.anngen.2004.05.004

Cited by 18 publications

(10 citation statements)

References 19 publications

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“…Clinical and biochemical traits did not differ significantly when grouped according to genotypic and allelic distributions of the polymorphisms. These results differ from those previously observed in a Mexican population in which the Mae III polymorphism was associated with hyperinsulinemia and the Pst I polymorphism was associated with hypertriglyceridemia and the presence of at least one component of metabolic syndrome [24] , and in a Mexican ethnic group in which Pst I and Nsi I polymorphisms were associated with increased serum insulin levels [22] . We believe that these contrasting results were probably caused by the stringent selection criteria that we applied.…”

Section: Discussioncontrasting

confidence: 57%

Analysis of the Association of Preeclampsia with Polymorphisms of the INS, INSR and IRS1 Genes in Mexican Women

Machorro-Lazo¹,

Sánchez‐Corona²,

Martı́nez-Abundis

et al. 2008

Gynecol Obstet Invest

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Background/Aims: It has been proposed that preeclampsia is a metabolic syndrome of pregnancy. The polymorphisms PstI and MaeIII of INS, NsiI of INSR and Ala513Pro and Gly972Arg of IRS1 have been associated with metabolic syndrome; moreover, the products of these genes are functionally contiguous during insulin signaling. The aim of this study was to assess whether these polymorphisms are associated with preeclampsia. Methods: 46 normotensive pregnant women and 43 preeclamptic patients were included in the study to develop a clinical, biochemical and genotypic profile of preeclampsia. Clinical evaluation consisted of measurement of blood pressure, height and weight. Peripheral blood samples were collected for determination of fasting glucose and insulin concentrations and for extraction of genomic DNA. Proteinuria was determined. Polymorphisms were detected using PCR-RFLP. Results: The normotensive and preeclampsia groups did not differ significantly in clinical and biochemical traits, except for systolic and diastolic blood pressure (p < 0.0001). Polymorphisms previously associated with metabolic syndrome in Mexican populations were not associated with preeclampsia in Mexican women (p > 0.05). Conclusion: The lack of an association between preeclampsia and the polymorphisms studied suggests that other genes whose products do not have direct functional interaction with metabolic syndrome or epigenetic factors may play a role in preeclampsia.

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Section: Discussioncontrasting

confidence: 57%

Analysis of the Association of Preeclampsia with Polymorphisms of the INS, INSR and IRS1 Genes in Mexican Women

Machorro-Lazo¹,

Sánchez‐Corona²,

Martı́nez-Abundis

et al. 2008

Gynecol Obstet Invest

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“…However, in South Indian individuals, this SNP is associated with type 2 diabetes mellitus (Bodhini et al, 2012). Within Mexican ethnic groups, rs2059806 showed no association with type 2 diabetes (Flores-Martinez et al, 2004). However, in our study, this SNP was not only associated with type 2 diabetes mellitus, but also with type 2 diabetic nephropathy.…”

Section: Discussioncontrasting

confidence: 47%

Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population

Zhu¹,

Yang²,

Sun³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We explored the associations of INSR and mTOR, 2 key genes in the insulin signaling pathway, and the susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Three single-nucleotide polymorphisms (SNPs) (rs1799817, rs1051690, and rs2059806) in INSR and 3 SNPs (rs7211818, rs7212142, and rs9674559) in mTOR were genotyped using the Sequenom MassARRAY iPLEX platform in 89 type 2 diabetes patients without diabetic nephropathy, 134 type 2 diabetes patients with diabetic nephropathy, and 120 healthy control subjects. Statistical analysis based on unconditional logistic regression was carried out to determine the odds ratio (OR) and 95% confidence interval (95%CI) for each SNP. Combination analyses between rs2059806 and rs7212142 were also performed using the c 2 test and logistic regression. Among these 6 SNPs, 4 (rs1799817, rs1051690, rs7211818, and rs9674559) showed no INSR and MTOR associated with T2DM and type 2 DN association with type 2 diabetes mellitus or diabetic nephropathy. However, rs2059806 in INSR was associated with both type 2 diabetes mellitus (P = 0.033) and type 2 diabetic nephropathy (P = 0.018). The rs7212142 polymorphism in mTOR was associated with type 2 diabetic nephropathy (P = 0.010, OR = 0.501, 95%CI = 0.288-0.871), but showed no relationship with type 2 diabetes mellitus. Combination analysis revealed that rs2059806 and rs7212142 had a combined effect on susceptibility to type 2 diabetes mellitus and diabetic nephropathy. Our results suggest that both INSR and mTOR play a role in the predisposition of the Han Chinese population to type 2 diabetic nephropathy, but the genetic predisposition may show some differences.

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“…Data for the two small samples of Mixtecs are variable. Overweight and obesity in Zapotec adults are more prevalent than corresponding estimates for one sample (Schulz and Weidensee, 1995), whereas obesity is especially more prevalent in another sample of Mixtec adults (Flores-Martinez et al, 2004). Overweight in Zapotec adults is more prevalent than in Pima Indians from Sonora in northern Mexico, but the prevalence of obesity is similar in Zapotec and Pima males and higher in Pima than Zapotec females (Schulz et al, 2006).…”

Section: Discussionmentioning

confidence: 74%

Overweight and obesity in a rural amerindian population in Oaxaca, Southern Mexico, 1968–2000

Malina¹,

Reyes²,

Tan³

et al. 2007

American J Hum Biol

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The purpose of this study was to evaluate secular change in the prevalence of overweight and obesity in a rural Zapotec Indian community in southern Mexico between 1968 and 2000. Cross-sectional surveys of children 6-13 years, adolescents 13-17 years, and adults 19 years of age and older resident in a rural community in Oaxaca were conducted in 1968/1971, 1978, and 2000. Individuals present in the 1968, 1978, and 2000 surveys provided a small longitudinal component. Height and weight were measured; the BMI was calculated. International criteria for overweight and obesity were used. Overweight and obesity were virtually absent in school children 6-13 years in 1968 and 1978 and in adolescents in 1978. Small proportions of children (boys, 5%; girls, 8%) and adolescents (boys, 3%; girls, 15%) were overweight in 2000; two children (1%) and no adolescents were obese. Among adults, 7% of males and 19% of females were overweight and <1% of males and 4% of females were obese in 1971/1978, but 46% of males and 47% of females were overweight; and 5% of males and 14% of females were obese in 2000. The trends for children, adolescents, and adults were confirmed in the longitudinal subsamples. In conclusion, overweight and obesity are not presently a major problem in children and adolescents in this rural Zapotec community. Overweight, in particular, and to a lesser extent obesity have increased in prevalence among adults since the late 1970s. The results suggest adulthood as a critical period for onset of overweight and obesity in this sample.

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DNA polymorphism analysis of candidate genes for type 2 diabetes mellitus in a Mexican ethnic group

Cited by 18 publications

References 19 publications

Analysis of the Association of Preeclampsia with Polymorphisms of the <i>INS</i>, <i>INSR </i>and <i>IRS1 </i>Genes in Mexican Women

Analysis of the Association of Preeclampsia with Polymorphisms of the <i>INS</i>, <i>INSR </i>and <i>IRS1 </i>Genes in Mexican Women

Associations between INSR and MTOR polymorphisms in type 2 diabetes mellitus and diabetic nephropathy in a Northeast Chinese Han population

Overweight and obesity in a rural amerindian population in Oaxaca, Southern Mexico, 1968–2000

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