DNA Oxidation and Antioxidant Status in Breast Cancer

Himmetoglu, Solen; Dinçer, Yıldız; Ersoy, Yeliz Emine; Bayraktar, Baris; Çelik, Varol; Akçay, Tülay

doi:10.2310/jim.0b013e3181adfb5b

Cited by 33 publications

(21 citation statements)

References 23 publications

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“…The role of free radicals, oxidative stress, and lipid peroxidation in carcinogenesis and their contribution to the initiation and progression of the process are well documented (Himmetoglu et al, 2009). In recent years, using MDA as a marker of oxidative stress, there has been a growing interest in studying the role played by lipid peroxidation in cancer progression.…”

Section: Discussionmentioning

confidence: 99%

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Gupta¹,

Patel²,

Kumari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDLcholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Gupta¹,

Patel²,

Kumari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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show abstract

“…It has been suggested that oxidative stress can cause DNA damage followed by an increase in the spontaneous mutation rate, which is a platform for tumor genesis [8][9][10]. 8-Hydroxy-2′-deoxyguanosine (8-OHdG) used as a biomarker for the measurement of endogenous oxidative DNA damage has been found to be significantly higher in various cancers [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

et al. 2014

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The aim of this study was to determine levels of serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) as an indicator of oxidant-induced DNA damage and oxidant status in patients with papillary thyroid carcinoma before and after surgery. This study included 25 patients with papillary thyroid carcinoma and age-matched 27 healthy controls. Total antioxidant status (TAS), total oxidant status (TOS), lipid hydroperoxide (LOOH), and 8-OHdG levels were measured. 8-OHdG levels were significantly higher in the preoperative papillary thyroid carcinoma (PTC) group compared with the healthy control group (p < 0.001) and were significantly lower after operation in patients with papillary thyroid carcinoma (p = 0.004). Oxidative stress index (OSI) levels were significantly higher in both preoperative and postoperative PTC patients compared with the healthy control group (p < 0.001 and p < 0.001, respectively). TOS levels were higher in the preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). TAS levels was lower in the preoperative PTC groups compared to the healthy control group (p = 0.011). Serum LOOH levels were higher in both preoperative and postoperative PTC groups compared to the healthy control group (p < 0.001 and p < 0.001, respectively). Correlation analysis yielded that serum 8-OHdG levels were positively correlated with OSİ and LOOH levels in patients with PTC before surgery (r = 0.668, p < 0.001; r = 0.446, p = 0.025, respectively) and had a negative correlation with TAS levels (r = -0.616, p = 0.001). We have shown severe oxidative DNA damage and impaired antioxidant status in papillary thyroid carcinoma.

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“…14,15 The oxidative stress, detected by using various biomarkers (including the level of carbonyl groups and 3-nitrotyrosine in proteins, the total antioxidant level (TAS), the activity of antioxidative enzymes), had been observed in breast cancer patients before and during different phases of treatment. [7][8][9][10][11][12][13][16][17][18][19][20][21][22][23] Results of Kedzierska et al 11 have shown that the total level of glutathione (an important physiological antioxidant) in plasma isolated from breast cancer patients (before and during treatment, during different phases of chemotherapy (doxorubicin and cyclophosphamide)) was lower than in healthy persons.…”

Section: Oxidative Stress In Breast Cancermentioning

confidence: 99%

Role of Black Chokeberries in Breast Cancer

Olas

2014

Cancer

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DNA Oxidation and Antioxidant Status in Breast Cancer

Cited by 33 publications

References 23 publications

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Investigation of the role of 8-OHdG and oxidative stress in papillary thyroid carcinoma

Role of Black Chokeberries in Breast Cancer

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