DNA Origami with Complex Curvatures in Three-Dimensional Space

Han, Dongran; Pal, Soumik; Nangreave, Jeanette; Deng, Zhengtao; Liu, Yan

doi:10.1126/science.1202998

Cited by 1,082 publications

(909 citation statements)

References 21 publications

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“…Other DNA structures utilizing such novel complex curvature have similarly been designed [10]. A 3D space to outline curved surfaces was used to manipulate DNA such that it bent around the contours of any particular target object.…”

Section: Dna Origamimentioning

confidence: 99%

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Beyond the smiley face: applications of structural DNA nanotechnology

Arora

Silva

2018

Nano Reviews & Experiments

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Since the development of DNA origami by Paul Rothemund in 2006, the field of structural DNA nanotechnology has undergone tremendous growth. Through DNA origami and related approaches, self-assembly of specified DNA sequences allows for the ‘bottom-up’ construction of diverse nanostructures. By utilizing different sets of small ‘staple’ DNA strands to direct the folding of a long scaffold strand in diverse ways, DNA origami has particularly been incorporated into a variety of prototypical applications beyond the two-dimensional (2D) smiley face. In this review, the basis of DNA nanotechnology, methods of self-assembly, and Rothemund’s DNA origami breakthrough are discussed first. Next, some of the most promising applications of structural DNA nanotechnology since 2006 are summarized. These include utilizing DNA origami as a tool for creating 3D nanostructures (including DNA bricks), as well as structural (ligand capsid binding, viral capsid binding, DNA NanoOctahedron, DNA mold, photonic devices, energy transfer units), and dynamic (DNA box-with-lid, DNA nano-robot, DNA barges, amphipathic DNA structures, DNA nanocircuits) applications of DNA origami.

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Section: Dna Origamimentioning

confidence: 99%

“…Now, the latitudinal curvature (2D concentric rings or ‘in-plane’ curvature) and longitudinal curvature (‘out-of-plane’ curvature) was created. Three dimensional structures such as nanoflasks, spherical shells, and ellipsoidal shells have been generated using this technique [10]. …”

Section: Dna Origamimentioning

confidence: 99%

Beyond the smiley face: applications of structural DNA nanotechnology

Arora

Silva

2018

Nano Reviews & Experiments

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“…molecules or nanoparticles, to spontaneously arrange with spacings and positions governed by interparticle and particle-substrate interactions. [76][77][78] Inherent drawbacks of this method are a nite amount of defects and also an inability to use molecules whose interactions do not permit self-assembly. This can be overcome by using directed self-assembly, in which a structure is pre-patterned, directing the building blocks to specic locations on the substrate.…”

Section: Nanofabricationmentioning

confidence: 99%

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

et al. 2014

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This feature article discusses the optical trapping and manipulation of plasmonic nanoparticles, an area of current interest with potential applications in nanofabrication, sensing, analytics, biology and medicine. We give an overview over the basic theoretical concepts relating to optical forces, plasmon resonances and plasmonic heating. We discuss fundamental studies of plasmonic particles in optical traps and the temperature profiles around them. We place a particular emphasis on our own work employing optically trapped plasmonic nanoparticles towards nanofabrication, manipulation of biomimetic objects and sensing.

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“…Increasingly complex 2D and 3D architectures were made -including multilayer lattices 4 , polyhedral cages 5 and a self-assembled DNA nanobox bearing a dynamic and controllable lid 6 . Controlled curvature was achieved in both two and three dimensions to generate shapes such as concentric rings, spheres and ellipsoids 7 . In another variation, 'DNA kirigami' -the folding and cutting of DNA into reconfigurable topological nanostructureswas applied for the synthesis of a Möbius strip and catenated twisted cylinders 8 .…”

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confidence: 99%

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2016

Nature Mater

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editorialIt was a bold leap for Nadrian Seeman to suggest, over 30 years ago, that nucleic acids could be used to synthesize new and complex DNA-like constructs. The range of 2D and 3D DNA nanostructures that were soon fabricated, such as a planar lattice and a hollow cube, demonstrated the scientific and technological potential of harnessing the power of Watson-Crick base pairing, and heralded the arrival of DNA nanotechnology.With time, the synthesis of increasingly complex nanostructures put significant demands on traditional fabrication techniques, which typically relied on the stoichiometric combination of many short DNA strands. Intricate structures required many reactions with intermediate purification steps, which inevitably extended synthesis time frames and reduced product yields. These limitations prompted researchers to devise easier synthesis methods that could increase the structural complexity of DNA nanostructures. Works by Hao Yan 1 , William Shih 2 and their colleagues offered potential solutions: rather than relying on the bottom-up assembly of short DNA strands, they showed that lattices of DNA tiles could be assembled by means of a scaffold DNA strand encoding the desired pattern 1 , and that a linear DNA chain could be designed to fold into a predetermined shape 2 .These preliminary findings paved the way for Paul Rothemund's pivotal work, in which he presented the general principles of 'scaffolded DNA origami' and how it can be applied to the fabrication of twodimensional nanomaterials. Published in Nature 10 years ago this month 3 , the method appeared remarkably straightforward: a long single-stranded DNA scaffold could be designed, with relaxed stoichiometric constraints, to fold into any geometric pattern by means of short 'staple' strands (pictured). Complex shapes and patterns roughly 100 nm in diameter -such as Rothemund's five-pointed star, smiley face and even a map of the Americas 3 -could be made quickly, reliably, in high yield and with a spatial resolution of 6 nm. Rothemund's work gained immediate interest, inspiring others to explore the boundaries of the technique. Increasingly complex 2D and 3D architectures were made -including multilayer lattices 4 , polyhedral cages 5 and a self-assembled DNA nanobox bearing a dynamic and controllable lid 6 . Controlled curvature was achieved in both two and three dimensions to generate shapes such as concentric rings, spheres and ellipsoids 7 . In another variation, 'DNA kirigami' -the folding and cutting of DNA into reconfigurable topological nanostructureswas applied for the synthesis of a Möbius strip and catenated twisted cylinders 8 . In terms of geometry, there were seemingly few limitations to what could be achieved with DNA origami.Alongside the increasingly impressive demonstrations of shape control, functional applications were being investigated. By modifying frameworks with DNA sequences able to bind other nucleotide polymers (such as RNA), origami-based DNA nanomaterials have been successfully applied in single-molecule bi...

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DNA Origami with Complex Curvatures in Three-Dimensional Space

Cited by 1,082 publications

References 21 publications

Beyond the smiley face: applications of structural DNA nanotechnology

Beyond the smiley face: applications of structural DNA nanotechnology

Optical trapping and manipulation of plasmonic nanoparticles: fundamentals, applications, and perspectives

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