DNA Nanodevice-Based Drug Delivery Systems

Abstract

DNA, a natural biological material, has become an ideal choice for biomedical applications, mainly owing to its good biocompatibility, ease of synthesis, modifiability, and especially programmability. In recent years, with the deepening of the understanding of the physical and chemical properties of DNA and the continuous advancement of DNA synthesis and modification technology, the biomedical applications based on DNA materials have been upgraded to version 2.0: through elaborate design and fabrication of smart-responsive DNA nanodevices, they can respond to external or internal physical or chemical stimuli so as to smartly perform certain specific functions. For tumor treatment, this advancement provides a new way to solve the problems of precise targeting, controllable release, and controllable elimination of drugs to a certain extent. Here, we review the progress of related fields over the past decade, and provide prospects for possible future development directions.

Application Perspectives of Nanomedicine in Cancer Treatment

“…We take doxorubicin as an example to illustrate how DNA-based NPs deliver chemotherapeutic drugs. At present, DNA-based NPs of various shapes have been reported for the delivery of doxorubicin by virtue of the drug-embedding properties, covering RCA-based nanostructures ( Zhao et al, 2018 ), DNA tetrahedra ( Zhang J. et al, 2021 ), dendritic DNA nanostructures ( Li et al, 2020 ), and nanostructures based on DNA origami technology ( Liu J. et al, 2018 ), in which tubular and triangular DNA nanocarriers based on DNA origami technology have the characteristics of high drug loading ( Guan et al, 2021 ). Interestingly, DNA-based NPs with specific hydrodynamic dimensions and geometries (triangular DNA origami nanostructures) can passively accumulate in tumor tissues, showing excellent targeting ( Zhang et al, 2014 ; Jiang B. et al, 2019 ).…”

Pharmacologic therapies of ARDS: From natural herb to nanomedicine

“…DNA is a natural biomaterial that has become an ideal drug carrier for biomedicine due to its biocompatibility, biodegradability, and programmability. Due to their programmability and strictly following the principle of complementary base pairing, DNA nanodevices can be assembled into different geometries to cross the cell membrane into cells to exert their functions ( Guan et al, 2021 ). DNA nanodevices with artificial intelligence (AI) have attracted great interest, which may open a new chapter in precision medicine for ALI/ARDS.…”

Apricot polysaccharides as new carriers to make curcumin nanoparticles and improve its stability and antibacterial activity

“…As a result, it is necessary to fabricate water‐soluble well‐formulated colloidal delivery systems to improve the stability and bioavailability of Cur. Many researchers in food and pharmaceutical industries have designed the embedded Cur in drug delivery systems in liposomes (Peng et al., 2018), protein nanoparticles (Chen et al., 2016), microemulsions (Zhu et al., 2021), and other biomolecule‐based polymers (Huang, Jiang, et al., 2022; Yu & Huang, 2023) to overcome those drawbacks. Among them, the colloidal delivery system of encapsulating Cur by protein‐shell nanoparticles exhibits advantages over other types due to easy preparation, high loading capacity, and good stabilizing properties (Dai et al., 2019).…”