DNA microarray analyses of the effects of dietary proteins

Kato, Harubumi; Narasaka, Sachiko; Endo, Yoshie; Abe, Keiko; Arai, Soichi

doi:10.1002/biof.552210103

Cited by 6 publications

(3 citation statements)

References 5 publications

(7 reference statements)

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“…Among these, the induction of genes for synthesis and catabolism of cholesterol by gluten feeding were observed [112]. The effect of consumption of an enzymatically produced, hypoallergenic wheat flour on gene expression profiles in rats confirmed the safety of this novel food product [113, 114]. The source of protein either soy or casein had a profound impact on hepatic expressions of genes related to lipid metabolism, transcription factor, and antioxidization enzymes [73].…”

Section: Effects Of Protein Content and Quality Of Proteinsmentioning

confidence: 99%

The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver

Osada

2013

ISRN Nutrition

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Liver is the organ primarily responding to diet, and it is crucial in determining plasma carbohydrate, protein, and lipid levels. In addition, it is mainly responsible for transformation of xenobiotics. For these reasons, it has been a target of transcriptomic analyses. In this review, we have covered the works dealing with the response of mammalian liver to different nutritional stimuli such as fasting/feeding, caloric restriction, dietary carbohydrate, cholesterol, fat, protein, bile acid, salt, vitamin, and oligoelement contents. Quality of fats or proteins has been equally addressed, and has the influence of minor dietary components. Other compounds, not purely nutritional as those represented by alcohol and food additives, have been included due to their relevance in processed food. The influence has been studied not only on mRNA but also on miRNA. The wide scope of the technology clearly reflects that any simple intervention has profound changes in many metabolic parameters and that there is a synergy in response when more compounds are included in the intervention. Standardized arrays to systematically test the same genes in all studies and analyzing data to establish patterns of response are required, particularly for RNA sequencing. Moreover, RNA is a valuable, easy-screening ally but always requires further confirmation.

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Section: Effects Of Protein Content and Quality Of Proteinsmentioning

confidence: 99%

The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver

Osada

2013

ISRN Nutrition

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“…Eitsuka et al [84] showed that polyunsaturated fatty acids inhibit telomerase activity, thereby having an inhibiting influence on tumor development, because telomerase activity is mostly only present in cancer cells. Analysis of the effect of hypoallergenic wheat flour by Kato et al [62] demonstrated that the enzymes involved in cholesterol synthesis and catabolism were up-regulated in gluten-fed rats. Nowadays, many diet-regulated genes, e. g., glucose-6-phosphate dehydrogenase or NAD, are known to play a key role in the onset and progression of diseases.…”

Section: Discussionmentioning

confidence: 98%

Impact of microarray technology in nutrition and food research

Spielbauer

Stahl

2005

Mol. Nutr. Food Res.

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Microarrays have become standard tools for gene expression profiling as the mRNA levels of a large number of genes can be measured in a single assay. Many technical aspects concerning microarray production and laboratory usage have been addressed in great detail, but it remains still crucial to establish this technology in new research fields such as human nutrition and food-related areas. The correlation between diet and inter-individual variation in gene expression is an important and relatively unexplored issue in human nutrition. Therefore, nutritionists changed their research field dramatically from epidemiology and physiology towards the "omics" sciences. Nutrigenomics as a field of research is based on the complete knowledge of the human genome and refers to the entire spectrum of human genes that determine the interactions of nutrition with the organism. Nutrigenetics is based on the inter-individual, genetically determined differences in metabolism. Nutrigenomics and nutrigenetics carry the hope that individualized diet can improve human health and prevent nutrition-related diseases. In this article we give an overview of current DNA and protein microarray techniques (including fabrication, experimental procedure and data analysis), we describe their applications to nutrition and food research and point out the limitations, problems and pitfalls of microarray experiments.

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“…The ArrayTube platform presents the advantage of rapidly screening bacteria for the presence of antibiotic resistance genes known in gram-positive bacteria (Perreten et al 2005). The more generic GeneChip DNA microarray system has been utilized to test food safety by comparing the gene expression profiles among rats fed on 12% casein, 12% gluten, and protein-free diets for one week (Kato et al 2004). A gene-specific DNA microarray technique has been developed for the comprehensive detection of pathogenic vibrios that are natural inhabitants of warm coastal waters and shellfish.…”

Section: The Microarray Technology and Food Safetymentioning

confidence: 99%

cDNA microarray screening in food safety

Roy

Sen

2006

Toxicology

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The cDNA microarray technology and related bioinformatics tools presents a wide range of novel application opportunities. The technology may be productively applied to address food safety. In this mini-review article, we present an update highlighting the late breaking discoveries that demonstrate the vitality of cDNA microarray technology as a tool to analyze food safety with reference to microbial pathogens and genetically modified foods. In order to bring the microarray technology to mainstream food safety, it is important to develop robust user-friendly tools that may be applied in a field setting. In addition, there needs to be a standardized process for regulatory agencies to interpret and act upon microarray-based data. The cDNA microarray approach is an emergent technology in diagnostics. Its values lie in being able to provide complimentary molecular insight when employed in addition to traditional tests for food safety, as part of a more comprehensive battery of tests.

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DNA microarray analyses of the effects of dietary proteins

Cited by 6 publications

References 5 publications

The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver

The Use of Transcriptomics to Unveil the Role of Nutrients in Mammalian Liver

Impact of microarray technology in nutrition and food research

cDNA microarray screening in food safety

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