DNA Methylation-Regulated HOXC8’s Role in HER2-Positive Breast Cancer Function and its Contribution to Herceptin Resistance
Xiaofeng Xie,
Sijia Tang,
Zhengyang Yu
Abstract:Background: The epidermal growth factor receptor 2 (HER2) is overexpressed in 30% of breast cancers, and this overexpression is strongly correlated with a poor prognosis. Herceptin is a common treatment for HER2-positive breast cancer; however, cancer cells tend to adapt gradually to the drug, rendering it ineffective. The study revealed an association between the methylation status of the Homeobox C8 (HOXC8) gene and tumor development. Therefore, it is of paramount importance to delve into the interaction bet… Show more
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