Abstract:Background: Osteosarcomas commonly arise during the bone growth
and remodeling in puberty, making it plausible to infer the involvement
of epigenetic alterations in their development. Procedure: We
investigated DNA methylation and related genetic variants in 28 primary
osteosarcomas aiming to identify deregulated driver pathways.
Methylation and genomic data was obtained using the Illumina HM450K
beadchips and the TruSight One sequencing panel, respectively.
Results: Aberrant DNA methylation was spread through… Show more
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