DNA methylation modifications: mediation to stipulate pesticide toxicity

Mahna, Dolly; Puri, Sanjeev; Sharma, Shweta

doi:10.1007/s13762-020-02807-9

Cited by 10 publications

(5 citation statements)

References 92 publications

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“…There are numerous reviews describing the effects of exposure to chemical substances on the epigenetic system using laboratory models [7,[35][36][37][38][39][40][41][42], and epidemiological investigations [43][44][45][46][47]. The application of epigenetic investigations to chemical hazard assessment has not been progressing as quickly as the field of clinical epigenetics.…”

Section: Introductionmentioning

confidence: 99%

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Desaulniers

Vasseur

Jacobs

et al. 2021

IJMS

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Epigenetics involves a series of mechanisms that entail histone and DNA covalent modifications and non-coding RNAs, and that collectively contribute to programing cell functions and differentiation. Epigenetic anomalies and DNA mutations are co-drivers of cellular dysfunctions, including carcinogenesis. Alterations of the epigenetic system occur in cancers whether the initial carcinogenic events are from genotoxic (GTxC) or non-genotoxic (NGTxC) carcinogens. NGTxC are not inherently DNA reactive, they do not have a unifying mode of action and as yet there are no regulatory test guidelines addressing mechanisms of NGTxC. To fil this gap, the Test Guideline Programme of the Organisation for Economic Cooperation and Development is developing a framework for an integrated approach for the testing and assessment (IATA) of NGTxC and is considering assays that address key events of cancer hallmarks. Here, with the intent of better understanding the applicability of epigenetic assays in chemical carcinogenicity assessment, we focus on DNA methylation and histone modifications and review: (1) epigenetic mechanisms contributing to carcinogenesis, (2) epigenetic mechanisms altered following exposure to arsenic, nickel, or phenobarbital in order to identify common carcinogen-specific mechanisms, (3) characteristics of a series of epigenetic assay types, and (4) epigenetic assay validation needs in the context of chemical hazard assessment. As a key component of numerous NGTxC mechanisms of action, epigenetic assays included in IATA assay combinations can contribute to improved chemical carcinogen identification for the better protection of public health.

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Section: Introductionmentioning

confidence: 99%

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Desaulniers

Vasseur

Jacobs

et al. 2021

IJMS

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“…Occupational and non-occupational pesticide exposure, as well as chronic and high pesticide exposure in human beings, lead to altered genomic methylation. Various pesticides, including DDT, vinclozolin, methoxychlor, chlorpyrifos methyl, and organochlorine, have been reported to increase or decrease the epigenetic methylation pattern in human beings ( Mahna et al, 2021 ).…”

Section: Role Of Pesticides In Genetic Damagementioning

confidence: 99%

Current status of pesticide effects on environment, human health and it’s eco-friendly management as bioremediation: A comprehensive review

et al. 2022

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Pesticides are either natural or chemically synthesized compounds that are used to control a variety of pests. These chemical compounds are used in a variety of sectors like food, forestry, agriculture and aquaculture. Pesticides shows their toxicity into the living systems. The World Health Organization (WHO) categorizes them based on their detrimental effects, emphasizing the relevance of public health. The usage can be minimized to a least level by using them sparingly with a complete grasp of their categorization, which is beneficial to both human health and the environment. In this review, we have discussed pesticides with respect to their global scenarios, such as worldwide distribution and environmental impacts. Major literature focused on potential uses of pesticides, classification according to their properties and toxicity and their adverse effect on natural system (soil and aquatic), water, plants (growth, metabolism, genotypic and phenotypic changes and impact on plants defense system), human health (genetic alteration, cancer, allergies, and asthma), and preserve food products. We have also described eco-friendly management strategies for pesticides as a green solution, including bacterial degradation, myco-remediation, phytoremediation, and microalgae-based bioremediation. The microbes, using catabolic enzymes for degradation of pesticides and clean-up from the environment. This review shows the importance of finding potent microbes, novel genes, and biotechnological applications for pesticide waste management to create a sustainable environment.

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“…Effects of chlorohydrocarbon pesticides: DDT, most widely used persistent chlorohydrocarbon pesticide, though banned for the last forty years is still present in the bodies of every living organism on Earth. DDT and other chlorohydrocarbon pesticides alter epigenetic methylation patterns in humans [63] . Dwivedi et al [64] , during their research studies, found that in India, predominating preterm and caesarean deliveries are due to oxidative stress and genotoxicity in pregnant women caused by Chlorohydrocarbon pesticides.…”

Section: Impact Of Pesticides On Human Healthmentioning

confidence: 99%

How pesticides affect the environment and human: A review

2023

jecet

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To avoid hunger and meet the needs of the increasing global population (expected to be 9.76 billion by 2050), it is very necessary to increase agricultural production. Since 1960, the application of pesticides has been one of the factors that have improved agricultural production. Pesticides protect the crops from insects, fungi, bacteria, and competing weeds. The pesticide also protects the stored agricultural products from rodents and other pests. Out of more than 10,000 synthetic chemical compounds used as pesticides nowadays, about 2000 active ingredients in 60 classes of chemicals are used as pesticides globally. Pesticides are also used to protect citizens from vector-borne diseases. In 2021, about 4.2 million metric tonnes of pesticides will have been used as agrochemicals globally. Some of the applied pesticides that are toxic to humans persist for a very long time in the environment as they cannot be easily degraded or bio-accumulated. The residues of the pesticides or related daughter products are present in all the compartments of aquatic and terrestrial environments (soil, groundwater, surface water, food chain, sea products, vegetables, fruits, animal milk, and breast milk). When humans and other animal's uptake pesticide-contaminated food and water, the pesticides are bio accumulated in humans and animals. The exposure of humans and animals to pesticides may cause short-term effects such as headaches, nausea, asthma, sore throat, eye irritation, skin irritation, diarrhoea, pharyngitis, nasal irritation, sinusitis, contact dermatitis, or long-term effects related to growth, neurotoxicity, endocrine disruption, liver and kidney damage, breast, prostate, brain, liver cancer, and reproductive effects (sperm abnormalities, infertility, birth defects, abortion). For a better life, it is How pesticides… O.P. Bansal.

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DNA methylation modifications: mediation to stipulate pesticide toxicity

Cited by 10 publications

References 92 publications

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Current status of pesticide effects on environment, human health and it’s eco-friendly management as bioremediation: A comprehensive review

How pesticides affect the environment and human: A review

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