DNA methylation meta-analysis confirms the division of the genome into two functional groups

Salnikov, Lev; Goldberg, Saveli; Sukumaran, Parvathy; Pinsky, Eugene

doi:10.1101/2022.01.10.475724

Cited by 1 publication

(2 citation statements)

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“…In our previous work on genome methylation ( Salnikov et al, 2022 ) we obtained the results confirming significant differences in this parameter between functional groups HG and IntG, which decreases over time. Considering the fact that methylation itself reflects the processes of epigenetic regulation, the results showing the highest level of dispersion of its values in the reproductive age period also deserve attention.…”

Section: Discussionsupporting

confidence: 75%

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The RNA-Seq data analysis shows how the ontogenesis defines aging

Salnikov¹,

Goldberg

Rijhwani

et al. 2023

Front. Aging

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This paper presents a global statistical analysis of the RNA-Seq results of the entire Mus musculus genome. We explain aging by a gradual redistribution of limited resources between two major tasks of the organism: its self-sustenance based on the function of the housekeeping gene group (HG) and functional differentiation provided by the integrative gene group (IntG). All known disorders associated with aging are the result of a deficiency in the repair processes provided by the cellular infrastructure. Understanding exactly how this deficiency arises is our primary goal. Analysis of RNA production data of 35,630 genes, from which 5,101 were identified as HG genes, showed that RNA production levels in the HG and IntG genes had statistically significant differences (p-value <0.0001) throughout the entire observation period. In the reproductive period of life, which has the lowest actual mortality risk for Mus musculus, changes in the age dynamics of RNA production occur. The statistically significant dynamics of the decrease of RNA production in the HG group in contrast to the IntG group was determined (p-value = 0.0045). The trend toward significant shift in the HG/IntG ratio occurs after the end of the reproductive period, coinciding with the beginning of the mortality rate increase in Mus musculus indirectly supports our hypothesis. The results demonstrate a different orientation of the impact of ontogenesis regulatory mechanisms on the groups of genes representing cell infrastructures and their organismal functions, making the chosen direction promising for further research and understanding the mechanisms of aging.

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Section: Discussionsupporting

confidence: 75%

“…This group of genes is similar in its function to the Weisman cell line “Soma”. Confirmation of reliable differences between the functional groups we identified was presented in our previous work on genome methylation ( Salnikov et al, 2022 ).…”

Section: Introductionsupporting

confidence: 75%