DNA Methylation in the Pathogenesis of Head and Neck Cancer

Magić, Zvonko; Šupić, Gordana; Branković-Magić, Mirjana; Jović, N

doi:10.5772/51169

Cited by 4 publications

(13 citation statements)

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“…DNA methylation, the covalent addition of a methyl group (CH 3 ) to carbon in the 5 position of cytosine in the sequence 5′-CG-3′, is one of the most common epigenetic mechanisms (Fig. 1) (Momparler 2003;Luczak and Jagodziński 2006;Gopisetty et al 2006;Magić et al 2013). The targets of methylation may be in any type of DNA sequence such as intergenic DNA, genes, or non-coding repetitive sequences (Reyngold and Chan 2018).…”

Section: Methylation Of Dnamentioning

confidence: 99%

“…HNSCC is placed at sixth of the most frequent human malignancies and belongs to the most aggressive cancers. Worldwide, more than half a million new cases are diagnosed per year and nearly 50% of them have a less than 5-year survival rate (Leemans et al 2011;Ganci et al 2012;Magić et al 2013). Cancer cells spread to the oral cavity, larynx, naso-, hypo-, and oro-pharynx.…”

Section: Introductionmentioning

confidence: 99%

“…Cancer cells spread to the oral cavity, larynx, naso-, hypo-, and oro-pharynx. Environmental and genetic factors influence the development of HNSCC and the main lifestyle risk factors include Human Papilloma Virus (HPV) infection, age, diet, tobacco use, and alcohol intake (Demokan and Dalay 2011;Magić et al 2013;Koffler et al 2014). External factors like alcohol abuse and tobacco influence epigenetic patterns in some types of HNSCC like oral cancer (Ghantous et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common human malignancy in the world, with high mortality and poor prognosis for patients. Among the risk factors are tobacco and alcohol intake, human papilloma virus, and also genetic and epigenetic modifications. Many studies show that epigenetic events play an important role in HNSCC development and progression, including DNA methylation, chromatin remodeling, histone posttranslational covalent modifications, and effects of non-coding RNA. Epigenetic modifications may influence silencing of tumor suppressor genes by promoter hypermethylation, regulate transcription by microRNAs and changes in chromatin structure, or induce genome instability through hypomethylation. Moreover, getting to better understand aberrant patterns of methylation may provide biomarkers for early detection and diagnosis, while knowledge about target genes of microRNAs may improve the therapy of HNSCC and extend overall survival. The aim of this review is to present recent studies which demonstrate the role of epigenetic regulation in the development of HNSCC.

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Section: Methylation Of Dnamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epigenetic Modifications in Head and Neck Cancer

et al. 2019

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“…Age at DNA collection DNA methylation of several genes involved in cell cycle control has been associated with the risk for developing head and neck squamous cell cancer [18], in breast cancer where changes in peripheral blood have been reported years before breast cancer is diagnosed [19], in urocystic tumorgenesis [20], in non-polyposis colorectal cancer [21] and in germline epimutation of MLH1 in individuals with multiple cancers [22].…”

Section: Chracteristic Alcohol Dependence Yes (N = 33) Alcohol Dependmentioning

confidence: 99%

Cross-Generational Effects of Alcohol Dependence in Humans on HRAS and TP53 Methylation in Offspring

et al. 2017

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Aim:We hypothesized that cross-generational effects of alcohol exposure could alter DNA methylation and expression of the HRAS oncogene and TP53 tumor suppressor gene that drive cancer development. Methods: DNA methylation of the HRAS and TP53 genes was tested in samples from young participants (Mean age of 13.4 years). Results: Controlling for both personal use and maternal use of substances during pregnancy, familial alcohol dependence was associated with hypomethylation of CpG sites in the HRAS promoter region and hypermethylation of the TP53 gene. Conclusion: The results suggest that ancestral exposure to alcohol can have enduring effects that impact epigenetic processes such as DNA methylation that controls expression of genes that drive cancer development such as HRAS and TP53. Alcohol use is responsible for about 4% of all deaths worldwide [1]. A portion of this increased incidence of all-cause mortality is due to head and neck cancers, particularly of the pharynx, larynx, oral cavity and esophagus as well as the liver [2]. Alcohol abuse and dependence are frequently seen in individuals diagnosed with Head and Neck Squamous Cell Carcinoma [3]. Moreover, prospective epidemiological data show that alcohol use has a significant dose-response relationship with increased hazard ratios for developing cancer starting at three drinks per day [4]. Consumption of alcohol appears to have a direct effect on gastrointestinal tissue promoting the development of malignancy. The incidence of the head and neck cancers is in direct proportion to the dilution of alcohol in the gut so that mouth cancers are most common followed by esophageal cancers with the least incidence occurring in stomach and intestinal cancers [5].Integrated approaches to understanding cancer risk appear to require analysis of genetic and epigenetic factors along with gene expression profiles to address the complexity of cancer etiology [6]. In addition to the direct effect of alcohol on tissues exposed to alcohol, the potential exists for alcohol to change the methylation of oncogenes and tumor suppressor genes involved in tumor development. Defining the factors that contribute to this increased risk for these cancers is critical to the ultimate goal of reducing cancer development.A diverse set of environmental conditions affect DNA methylation [7][8][9] with the potential for altering gene expression [10]. Alcohol use and smoking can produce altered methylation in humans [11,12]. Cross generational effects have been reported with famine experienced by parents affecting medical conditions and longevity in offspring [13,14]. Although not previously reported in humans, animal studies have shown that ethanol administration can influence DNA methylation through the germline in offspring exposed either through fetal exposure [15] or as a result of paternal exposure [16,17]; changes with the potential to alter every somatic cell in the body across generations. Determining if alcohol consumption in the preconception period in parents influences genes involv...

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“…HNSCC as the most common smoking related cancer after lung cancer is one of the most aggressive malignancies in human population [1, 3] and causes about 438,000 smoking-attributable mortalities in the world each year. The most common anatomic site of HNSCC counting for approximately 50% of all HNSCC is oral squamous cell carcinoma (OSCC) which contains two most commonly diagnosed oral premalignant lesions (OPL) including Leukoplakia and erythroplakia [3].…”

Section: Introductionmentioning

confidence: 99%

High-Dimensional Additive Hazards Regression for Oral Squamous Cell Carcinoma Using Microarray Data: A Comparative Study

Hamidi

Tapak

Kohneloo

et al. 2014

BioMed Research International

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Microarray technology results in high-dimensional and low-sample size data sets. Therefore, fitting sparse models is substantial because only a small number of influential genes can reliably be identified. A number of variable selection approaches have been proposed for high-dimensional time-to-event data based on Cox proportional hazards where censoring is present. The present study applied three sparse variable selection techniques of Lasso, smoothly clipped absolute deviation and the smooth integration of counting, and absolute deviation for gene expression survival time data using the additive risk model which is adopted when the absolute effects of multiple predictors on the hazard function are of interest. The performances of used techniques were evaluated by time dependent ROC curve and bootstrap .632+ prediction error curves. The selected genes by all methods were highly significant (P < 0.001). The Lasso showed maximum median of area under ROC curve over time (0.95) and smoothly clipped absolute deviation showed the lowest prediction error (0.105). It was observed that the selected genes by all methods improved the prediction of purely clinical model indicating the valuable information containing in the microarray features. So it was concluded that used approaches can satisfactorily predict survival based on selected gene expression measurements.

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DNA Methylation in the Pathogenesis of Head and Neck Cancer

Cited by 4 publications

References 139 publications

Epigenetic Modifications in Head and Neck Cancer

Epigenetic Modifications in Head and Neck Cancer

Cross-Generational Effects of Alcohol Dependence in Humans on HRAS and TP53 Methylation in Offspring

High-Dimensional Additive Hazards Regression for Oral Squamous Cell Carcinoma Using Microarray Data: A Comparative Study

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