DNA Methylation in Patients with Colorectal Cancer - Correlation with Some Clinical and Morphological Features and with Local Tumour Invasion

Mirchev, Milko; Kahl, Philip; Friedrichs, Nicolaus; Kotzev, Iskren; Buettner, Reinhard

doi:10.2478/v10153-010-0043-9

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The CIMP CRC subtype associates with a high frequency of CpG hypermethylation and is diagnosed based on the methylation status of various genes that participate in regulation of calcium transport ( CACNA1G ), proliferation ( IGF2 ), Wnt signaling ( NEUROG1 ), transcription activity ( RUNX3 ), and suppression of cytokine signaling ( 124 , 125 ). Hypermethylation of MLH1 involved in DNA mismatch repair, and TIMP3 , which inhibits metalloproteinases, also associate with the CIMP phenotype ( 126 ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, hypomethylation of the transposable DNA element long interspersed nuclear element-1 has been shown to activate the MET, RAB3IP , and CHRM3 proto-oncogenes in CRC metastases ( 136 ). Mirchev et al characterized the association between DNA methylation status of the MLH1, p16 INK , TIMP3 , and TPEF genes and various clinicomorphological features of CRC ( 126 ). These investigators reported hypermethylation of MLH1 and p16 INK in elderly patients; MLH1, p16 INK , and TIMP3 in proximal tumors; and p16 INK in poorly differentiated tumors.…”

Section: Discussionmentioning

confidence: 99%

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Mediterranean Diet: Prevention of Colorectal Cancer

et al. 2017

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Colorectal cancer (CRC) is the third most common cancer diagnosis and the second and third leading cause of cancer mortality in men and women, respectively. However, the majority of CRC cases are the result of sporadic tumorigenesis via the adenoma–carcinoma sequence. This process can take up to 20 years, suggesting an important window of opportunity exists for prevention such as switching toward healthier dietary patterns. The Mediterranean diet (MD) is a dietary pattern associated with various health benefits including protection against cardiovascular disease, diabetes, obesity, and various cancers. In this article, we review publications available in the PubMed database within the last 10 years that report on the impact of a MD eating pattern on prevention of CRC. To assist the reader with interpretation of the results and discussion, we first introduce indexes and scoring systems commonly used to experimentally determine adherence to a MD, followed by a brief introduction of the influence of the MD pattern on inflammatory bowel disease, which predisposes to CRC. Finally, we discuss key biological mechanisms through which specific bioactive food components commonly present in the MD are proposed to prevent or delay the development of CRC. We close with a discussion of future research frontiers in CRC prevention with particular reference to the role of epigenetic mechanisms and microbiome related to the MD eating pattern.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mediterranean Diet: Prevention of Colorectal Cancer

et al. 2017

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“…Since its postulation by Toyota et al in 1999 [74], current investigations have increasingly focused on what is known as the CpG island methylator phenotype (CIMP) of tumor suppressor genes involved in CRC. More recent studies have revealed that numerous genes are hypermethylated at their promoter regions and silenced in CRC [75-78]. These include regulators of DNA mismatch repair such as MLH1 and MGMT (O 6 -methylguanine-DNA methyltransferase), and negative regulators of Wnt signaling such as Wnt inhibitory factor 1 ( WIF1 ) [79].…”

Section: Dna Methylationmentioning

confidence: 99%

Microbiota impact on the epigenetic regulation of colorectal cancer

Yang

Owen

Lightfoot

et al. 2013

Trends in Molecular Medicine

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Mechanisms of colorectal cancer (CRC) development can be roughly divided into three categories: genetic, epigenetic, and aberrant immunologic signaling pathways, all of which may be triggered by an imbalanced intestinal microbiota. Aberrant gut microbial composition, termed “dysbiosis”, has been reported in inflammatory bowel disease patients who are at increased risk for CRC development. Recent studies indicate that it is feasible to rescue experimental models of colonic cancer by oral treatment with genetically engineered beneficial bacteria and/or their immune-regulating gene products. Here, we review the mechanisms of epigenetic modulation implicated in the development and progression of CRC, which may be the result of dysbiosis, and therefore, may be amenable to therapeutic intervention.

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“…F. nucleatum was also found concerning DNA methylation by targeting innate immune signaling [187]. Several investigations of CRC epigenome have introduced numerous aberrant methylated genes in CRC cases, such as RAAS F2A , WIF1 , ALX4 , MGM2 , APC , RUNX3 , p14 , p16 , SOX2 , and NDRG4 [188,189,190]. It is noteworthy that aberrant methylation of cMyc gene, encoding the c-myc oncoprotein, has been detected in CRC cases [191].…”

Section: The Role Of Bacterial Metabolites In Epigenetic Modificatmentioning

confidence: 99%

Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?

et al. 2019

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Colorectal cancer (CRC) is a worldwide health concern which requires efficient therapeutic strategies. The mechanisms underlying CRC remain an essential subject of investigations in the cancer biology field. The evaluation of human microbiota can be critical in this regard, since the disruption of the normal community of gut bacteria is an important issue in the development of CRC. However, several studies have already evaluated the different aspects of the association between microbiota and CRC. The current study aimed at reviewing and summarizing most of the studies on the modifications of gut bacteria detected in stool and tissue samples of CRC cases. In addition, the importance of metabolites derived from gut bacteria, their relationship with the microbiota, and epigenetic modifications have been evaluated.

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DNA Methylation in Patients with Colorectal Cancer - Correlation with Some Clinical and Morphological Features and with Local Tumour Invasion

Cited by 6 publications

References 20 publications

Mediterranean Diet: Prevention of Colorectal Cancer

Mediterranean Diet: Prevention of Colorectal Cancer

Microbiota impact on the epigenetic regulation of colorectal cancer

Gut Bacteria and their Metabolites: Which One Is the Defendant for Colorectal Cancer?

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