DNA methylation in neonates born to women receiving psychiatric care

Schroeder, James W.; Smith, Alicia K.; Brennan, Patricia A.; Conneely, Karen N.; Kilaru, Varun; Knight, Bettina T.; Newport, D. Jeffrey; Cubells, Joseph F.; Stowe, Zachary N.

doi:10.4161/epi.19551

Cited by 67 publications

(81 citation statements)

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“…24 In contrast, the prior study identified two CpG sites associated with SSRI use, one located in a tumor necrosis factor receptor subfamily 21 (TNFRSF21) and the other in a cholinergic receptor, nicotinic, alpha2 (CHRNA2). In their study, both of these sites had very small differences between groups (1-3%).…”

Section: Discussionmentioning

confidence: 89%

“…23 To our knowledge, genome-wide DNA methylation patterns related to exposure to maternal depression in the developing fetus have only been considered in one study. 24 This study examined DNA methylation in the neonatal cord blood of the children of 201 women, all with lifetime diagnosis of a mood disorder, 43% with prenatal major depressive episode, and 75% on antidepressant medications. They did not find any significant DNA methylation changes in neonatal cord blood resulting from either maternal depressive symptoms or psychiatric diagnosis, using the 27K Illumina Infinium Methylation BeadChip.…”

Section: Introductionmentioning

confidence: 99%

“…Very small DNA methylation differences (~2-3%) at a few genes were associated with antidepressant treatment. 24 More epigenomic analyses are warranted to improve our understanding of the associations between depression, anxiety, antidepressants, and DNA methylation.…”

Section: Introductionmentioning

confidence: 99%

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Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy

et al. 2014

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

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Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy

et al. 2014

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“…Although there is substantial evidence suggesting that prenatal psychological stress, anxiety, and depression may be associated with the epigenetic profile of the newborn, not all EWAS support this notion. For example, a study of 201 mother-infant dyads found no significant correlation between maternal psychiatric diagnosis or depressive symptoms during pregnancy and gene-specific DNA methylation patterns in the neonatal cord blood of the infant [51]. The lack of consensus in the results of EWAS to date suggests that further research is warranted.…”

Section: Proposed Biological Mechanisms: Epigeneticsmentioning

confidence: 99%

The impact of psychological distress during pregnancy on the developing fetus: biological mechanisms and the potential benefits of mindfulness interventions

Isgut

Smith

Reimann

et al. 2017

Journal of Perinatal Medicine

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Abstract:The in utero environment plays an essential role in shaping future growth and development. Psychological distress during pregnancy has been shown to perturb the delicate physiological milieu of pregnancy, and has been associated with negative repercussions in the offspring, including adverse birth outcomes, long-term defects in cognitive development, behavioral problems during childhood and high baseline levels of stress-related hormones. Fetal epigenetic programming, involving epigenetic processes, may help explain the link between maternal prenatal stress and its negative effects on the child. Given the potential long-term effects of early-life stress on a child's health, it is crucial to minimize maternal distress during pregnancy. A number of recent studies have examined the usefulness of mindfulness-based programs to reduce prenatal psychological stress and improve maternal psychological health, and these are reviewed here. Overall, the findings are promising, but more research is needed with large studies using randomized controlled study designs. It remains unclear whether or not such interventions could also improve child health outcomes, and whether these changes are modulated at the epigenetic level during fetal development. Further studies in this area are needed.

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“…In a genomewide study of infant DNA methylation, Schroeder et al (2012) suggest that there are no large effects of maternal psychiatric illness, depressive symptoms, or prenatal exposure to antidepressants on neonatal DNA methylation in 201 infant DNA samples collected at delivery from peripheral blood.…”

Section: G Genome Association Studiesmentioning

confidence: 99%