DNA methylation in lymphoma: an opportunity?

Ansell, Stephen M.

doi:10.1182/blood-2015-02-625293

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…Selection for yield [ 15 ], higher levels of confinement, and shifts in housing and feeding stratagies [ 16 ] are unfavorably associated with cow health and wellbeing. Emerging evidence from humans has shown a role for epigenetics in important cattle diseases [ 17 ] such as metabolic failure [ 18 , 19 ], respiratory infection [ 20 ], and lymphoma [ 21 ], but this has not been studied extensively in livestock species.…”

Section: Introductionmentioning

confidence: 99%

DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield

Dechow

Liu

2018

BMC Genomics

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BackgroundMilk yield for Holstein cows has doubled over five decades due to genetic selection and changes to management, but the molecular mechanisms that facilitated this increase are mostly unknown. Epigenetic modifications to the cattle genome are a plausible molecular mechanism to cause variation in milk yield and our objective was to describe genome-wide DNA methylation patterns in peripheral blood mononuclear cells (PBMC) from mature Holstein dairy cows with variable milk yield.ResultsWhole genome MeDIP-seq was performed following DNA extraction from PBMC of 6 lactating dairy cows from 4 different herds that varied in milk yield from 13,556 kg to 23,105 kg per 305 day lactation. We describe methylation across the genome and for 13,677 protein coding genes. Repetitive element reads were primarily mapped to satellite (36.4%), SINE (29.1%), and LINE (23.7%) regions and the majority (78.4%) of CpG sites were sequenced at least once. DNA methylation was generally low upstream of genes with the nadir occurring 95 bp prior to the transcription start site (TSS). Methylation was lower in the first exon than in later exons, was highest for introns near the intron-exon junctions, and declined downstream as the distance from the gene increased. We identified 72 differentially methylated regions (DMR) between high milk yield cows and their control, and 252 DMR across herd environments.ConclusionsThis reference methylome for cattle with extreme variation in milk yield phenotype provides a resource to more fully evaluate relationships between DNA methylation and phenotype in populations subject to selection. The detection of DMR in cows of varying milk yield suggests potential to exploit epigenetic variation in cattle improvement programs.Electronic supplementary materialThe online version of this article (10.1186/s12864-018-5124-9) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield

Dechow

Liu

2018

BMC Genomics

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Indications to Epigenetic Dysfunction in the Pathogenesis of Common Variable Immunodeficiency

Rae

2016

Arch. Immunol. Ther. Exp.

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Primary immunodeficiencies (PIDs) are a group of rare genetic diseases resulting in the impairment of one or more functions of the human immune system. Common variable immunodeficiency (CVID) is one of the most prevalent PIDs, yet despite extensive genetic analysis, most patients do not have a monogenetic diagnosis. This has led to the theory that CVID must be a polygenetic condition. An alternative theory to a monogenetic or polygenetic underlying cause of CVID is that it is epigenetic phenomena that are causal in the majority of CVID patients. I will briefly discuss epigenetic regulation in B-cell biology and development, current examples of epigenetic diseases causing CVID-like primary antibody deficiencies, and how these observations may guide future investigation into the role of epigenetics in CVID.

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Methylation patterns in marginal zone lymphoma

Arribas

Bertoni

2017

Best Practice & Research Clinical Haematology

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DNA methylation in lymphoma: an opportunity?

Cited by 4 publications

References 9 publications

DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield

DNA methylation patterns in peripheral blood mononuclear cells from Holstein cattle with variable milk yield

Indications to Epigenetic Dysfunction in the Pathogenesis of Common Variable Immunodeficiency

Methylation patterns in marginal zone lymphoma

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