2014
DOI: 10.35652/igjps.2014.23
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DNA Methylation in Cancer: Review

Abstract: Mammalian genome has a profound effect of DNA methylation or covalent addition of a methyl group to cytosine with reference to CpG dinucleotide. These modifications are very stable but reversible. The effect of mutation of a number of Tumor suppressor gene (TSGs) can be mimicked by the change in methylation of promoter. Hypomethylation and

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