DNA methylation fine-tunes pro-and anti-inflammatory signalling pathways in inactive ulcerative colitis
Wei Meng,
Christopher G. Fenton,
Kay-Martin Johnsen
et al.
Abstract:Epigenetic changes, like DNA methylation, have been implied to play a role in the immune dysfunction associated with inflammatory bowel disease (IBD) and the disease development of ulcerative colitis (UC). Changes of the DNA methylation and correlated gene expression in patient samples with inactive UC might reveal possible regulatory features important for further treatment options for UC. Bisulfite sequencing and whole transcriptome sequencing were performed on mucosal biopsies from patients with active UC (… Show more
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