DNA methylation dataset of bovine embryonic fibroblast cells treated with epigenetic modifiers and divergent energy supply

Diniz, Wellison J. S.; Crouse, Matthew S; Caton, J. S.; Larson, Kate; Lindholm‐Perry, A. K.; Reynolds, Lawrence P.; Dahlen, Carl R; Borowicz, Paweł; Ward, Alison K

doi:10.1016/j.dib.2022.108074

Cited by 2 publications

(2 citation statements)

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“…Although most of the fetal size increase takes place in the last trimester, the first third of gestation is a critical period for organogenesis and tissue hyperplasia, as well as placentation [21,34,45,46], as shown in Figure 1. The prenatal growth trajectory of the conceptus is controlled by maternal nutrition either directly, by the provision of the essential nutrients; indirectly, via placental function, which regulates the transport of these nutrients [47]; or by altering the epigenetic mechanisms [48][49][50][51]. Pregnancy recognition occurs 15 to 16 days after estrous in cattle [58] and initiates maternal uterine vasculature changes to allow for the proper respiratory gas exchange and nutrient transfer to the developing embryo.…”

Section: Fetal Programming As a Multifactorial Systemmentioning

confidence: 99%

Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review

et al. 2023

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Maternal mineral nutrition during the critical phases of fetal development may leave lifetime impacts on the productivity of an individual. Most research within the developmental origins of the health and disease (DOHaD) field is focused on the role of macronutrients in the genome function and programming of the developing fetus. On the other hand, there is a paucity of knowledge about the role of micronutrients and, specifically, minerals in regulating the epigenome of livestock species, especially cattle. Therefore, this review will address the effects of the maternal dietary mineral supply on the fetal developmental programming from the embryonic to the postnatal phases in cattle. To this end, we will draw a parallel between findings from our cattle model research with data from model animals, cell lines, and other livestock species. The coordinated role and function of different mineral elements in feto-maternal genomic regulation underlies the establishment of pregnancy and organogenesis and, ultimately, affects the development and functioning of metabolically important tissues, such as the fetal liver, skeletal muscle, and, importantly, the placenta. Through this review, we will delineate the key regulatory pathways involved in fetal programming based on the dietary maternal mineral supply and its crosstalk with epigenomic regulation in cattle.

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Section: Fetal Programming As a Multifactorial Systemmentioning

confidence: 99%

Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review

et al. 2023

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“…Such epigenetic alterations are thought to 'program' not only fetal and postnatal growth and development, but also to cause long-term changes in organ structure (e.g. altered number of nephrons in the kidney, altered pancreatic islet number or size, altered number of myofibres) and function (Barker 1990;Paneth andSusser 1995, 2004;Armitage et al 2004;Wu et al 2006;Caton and Hess 2010;Reynolds et al 2010aReynolds et al , 2019Reynolds et al , 2022Reynolds and Caton 2012;Caton et al 2019;Dahlen et al 2021;Diniz et al 2022). The consequences of developmental programming include preterm delivery, low birth weight and poor survival of newborns as well as a host of chronic pathologies in the offspring including abnormal growth and body composition, behavioural or cognitive dysfunction, metabolic abnormalities and cardiovascular, gastro-intestinal, immune, musculoskeletal and reproductive dysfunction (Barker 2004;Wu et al 2006;Caton and Hess 2010;Reynolds et al 2010aReynolds et al , 2019Reynolds et al , 2022Reynolds and Caton 2012;Reynolds and Vonnahme 2016;Caton et al 2019;Cushman and Perry 2019;Dahlen et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Maternal nutrition and developmental programming of offspring

Reynolds

Diniz

Crouse

et al. 2022

Reprod. Fertil. Dev.

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Developmental programming is the concept that ‘stressors’ during development (i.e. pregnancy, the perinatal period and infancy) can cause long-term changes in gene expression, leading to altered organ structure and function. Such long-term changes are associated with an increased risk of a host of chronic pathologies, or non-communicable diseases including abnormal growth and body composition, behavioural or cognitive dysfunction, metabolic abnormalities, and cardiovascular, gastro-intestinal, immune, musculoskeletal and reproductive dysfunction. Maternal nutrition during the periconceptual period, pregnancy and postnatally can have profound influences on the developmental program. Animal models, including domestic livestock species, have been important for defining the mechanisms and consequences of developmental programming. One of the important observations is that maternal nutritional status and other maternal stressors (e.g. environmental temperature, high altitude, maternal age and breed, multiple fetuses, etc.) early in pregnancy and even periconceptually can affect not only embryonic/fetal development but also placental development. Indeed, altered placental function may underlie the effects of many maternal stressors on fetal growth and development. We suggest that future directions should focus on the consequences of developmental programming during the offspring’s life course and for subsequent generations. Other important future directions include evaluating interventions, such as strategic dietary supplementation, and also determining how we can take advantage of the positive, adaptive aspects of developmental programming.

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DNA methylation dataset of bovine embryonic fibroblast cells treated with epigenetic modifiers and divergent energy supply

Cited by 2 publications

References 3 publications

Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review

Maternal Mineral Nutrition Regulates Fetal Genomic Programming in Cattle: A Review

Maternal nutrition and developmental programming of offspring

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