“…7d). Differential methylation of the HOX clusters has been observed in a number of tissues, which includes adult brain, fetal brain, neonatal blood, whole-blood, T-lymphocytes, placenta, buccal epithelial cells, and neural induced pluripotent stem cell (iPSC) derivatives [26,27,[30][31][32][33][34][35]. DNMT3L DMRs mapping to HOXB7, HOXC4, HOXC5, HOXD10, and HOXD12 were present in the growth comparison, while those mapping to HOXD-AS2, HOTAIR ("HOX transcript antisense RNA" for the HOXC cluster), HOXC5, HOXC6, HOXC12, and HOXC13, and HOXD12 were present in the phase 1 comparison, and those mapping to HOTTIP ("HOXA distal transcript antisense RNA"), HOXC-AS2, HOXC-AS3, HOXC12, and HOTTAIR were present in the phase 3 comparison.…”