DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression

Lapato, Dana M.; Roberson‐Nay, Roxann; Kirkpatrick, Robert M.; Webb, Bradley T.; York, Timothy P.; Kinser, Patricia A.

doi:10.1186/s13148-019-0769-z

Cited by 9 publications

(4 citation statements)

References 69 publications

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“…25 Studies have linked DNAm to gene expression and disease processes, because DNAm can cause the gene to not be expressed (see Figure 3), and the removal of a methyl group can cause the gene to be expressed. [27][28][29] DNAm can be measured and compared using discrete methylation differential data. If comparing two cells, one from a disease process such as cancer and the other a control, the methylation of the exact same CpG site can be measured to determine the methylation level, which is reported as being hyper-methylated or hypo-methylated in the diseased cell.…”

Section: Epigeneticsmentioning

confidence: 99%

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Nursing Informatics and Epigenetics

Milner

Zadinsky

2022

CIN: Computers, Informatics, Nursing

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Section: Epigeneticsmentioning

confidence: 99%

“…DNAm can occur due to environmental exposure to toxins, diet, and existing diseases 25 . Studies have linked DNAm to gene expression and disease processes, because DNAm can cause the gene to not be expressed (see Figure 3), and the removal of a methyl group can cause the gene to be expressed 27–29 …”

Section: Epigeneticsmentioning

confidence: 99%

Nursing Informatics and Epigenetics

Milner

Zadinsky

2022

CIN: Computers, Informatics, Nursing

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“…During the postnatal period, associations between postpartum stress and depression and child DNA methylation have not been extensively studied despite the established relationship between postpartum maternal mental health and child development. While evidence of an association between postpartum depressive symptoms and numerous differentially methylated gene regions have been identi ed in two studies using next-generation sequencing 44 and the Illumina EPIC array 45 respectively, more EWASs, candidate gene studies, and large-scale meta-analyses have yet to be conducted.…”

Section: Introductionmentioning

confidence: 99%

Association between Maternal Perinatal Stress and Depression on Infant DNA Methylation in the First Year of Life

Abrishamcar,

Zhuang,

Thomas

et al. 2024

Preprint

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Maternal stress and depression during pregnancy and the first year of the infant’s life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal and childhood outcomes as well as differential child DNA methylation (DNAm). However, the biological mechanisms connecting maternal stress and depression to poor health outcomes in children are still largely unknown. Here we aim to determine whether prenatal stress and depression are associated with changes in cord blood mononuclear cell DNAm (CBMC-DNAm) in newborns (n = 119) and whether postnatal stress and depression are associated with changes in peripheral blood mononuclear cell DNAm (PBMC-DNAm) in children of 12 months of age (n = 113) from the Canadian Healthy Infant Longitudinal Development (CHILD) cohort. Stress was measured using the 10-item Perceived Stress Scale (PSS) and depression was measured using the Center for Epidemiologic Studies Depression Questionnaire (CESD). Both stress and depression were measured at 18 weeks and 36 weeks of pregnancy and six months and 12 months postpartum. We conducted epigenome-wide association studies (EWAS) using robust linear regression followed by a sensitivity analysis in which we bias-adjusted for inflation and unmeasured confounding using the bacon and cate methods. To investigate the cumulative effect of maternal stress and depression, we created composite prenatal and postnatal adversity scores. We identified a significant association between prenatal stress and differential CBMC-DNAm at 8 CpG sites and between prenatal depression and differential CBMC-DNAm at 2 CpG sites. Additionally, we identified a significant association between postnatal stress and differential PBMC-DNAm at 8 CpG sites and between postnatal depression and differential PBMC-DNAm at 11 CpG sites. Using our composite scores, we further identified 2 CpG sites significantly associated with prenatal adversity and 7 CpG sites significantly associated with postnatal adversity. Several of the associated genes, including PLAGL1, HYMAI, BRD2, and ERC2 have been implicated in adverse fetal outcomes and neuropsychiatric disorders. This suggested that differential DNAm may play a role in the relationship between maternal mental health and child health.

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“…Postpartum depression (PPD) is a common mood disorder that occurs in 10–15% of pregnant women 2 . As per the Diagnostic and Statistical Manual (DSM-5, fifth edition), PPD is defined as a major depressive episode that occurs within 4 weeks post-delivery 3 , however many studies investigate depressive symptoms up to 1 year postpartum 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

et al. 2021

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Maternal postpartum depression (PPD) is a significant public health concern due to the severe negative impact on maternal and child health and well-being. In this study, we aimed to identify genes associated with PPD. To do this, we investigated genome-wide gene expression profiles of pregnant women during their third trimester of pregnancy and tested the association of gene expression with perinatal depressive symptoms. A total of 137 women from a cohort from the University of North Carolina, USA were assessed. The main phenotypes analysed were Edinburgh Postnatal Depression Scale (EPDS) scores at 2 months postpartum and PPD (binary yes/no) based on an EPDS cutoff of 10. Illumina NextSeq500/550 transcriptomic sequencing from whole blood was analysed using the edgeR package. We identified 71 genes significantly associated with postpartum depression scores at 2 months, after correction for multiple testing at 5% FDR. These included several interesting candidates including TNFRSF17, previously reported to be significantly upregulated in women with PPD and MMP8, a matrix metalloproteinase gene, associated with depression in a genome-wide association study. Functional annotation of differentially expressed genes revealed an enrichment of immune response-related biological processes. Additional analysis of genes associated with changes in depressive symptoms from recruitment to 2 months postpartum identified 66 genes significant at an FDR of 5%. Of these genes, 33 genes were also associated with depressive symptoms at 2 months postpartum. Comparing the results with previous studies, we observed that 15.4% of genes associated with PPD in this study overlapped with 700 core maternal genes that showed significant gene expression changes across multiple brain regions (P = 7.9e-05) and 29–53% of the genes were also associated with estradiol changes in a pharmacological model of depression (P values range = 1.2e-4–2.1e-14). In conclusion, we identified novel genes and validated genes previously associated with oestrogen sensitivity in PPD. These results point towards the role of an altered immune transcriptomic landscape as a vulnerability factor for PPD.

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DNA methylation associated with postpartum depressive symptoms overlaps findings from a genome-wide association meta-analysis of depression

Cited by 9 publications

References 69 publications

Nursing Informatics and Epigenetics

Nursing Informatics and Epigenetics

Association between Maternal Perinatal Stress and Depression on Infant DNA Methylation in the First Year of Life

Genome-wide gene expression changes in postpartum depression point towards an altered immune landscape

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