DNA methylation and psychotherapy response in trauma-exposed men with appetitive aggression

Xulu, Khethelo Richman; Womersley, Jacqueline S.; Sommer, Jessica; Hinsberger, Martina; Elbert, Thomas; Kaminer, Debra; Malan‐Müller, Stefanie; Seedat, Soraya; Hemmings, Sian

doi:10.1016/j.psychres.2020.113608

Cited by 8 publications

(4 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Narrative exposure therapy. The three studies included that used NET for community trauma were all based on one trial (Hinsburger et al, 2017(Hinsburger et al, , 2020Xulu et al, 2021). They used the Forensic Offender Rehabilitation Narrative Exposure Therapy (FORNET) which focused on reducing trauma symptoms as well as aggressive behaviors among traumatized ex-offenders in South Africa.…”

Section: Adultsmentioning

confidence: 99%

The Effectiveness and Feasibility of Psychological Interventions for Populations Under Ongoing Threat: A Systematic Review

Yim

Lorenz

Šalkovskis

2023

Trauma, Violence, & Abuse

View full text Add to dashboard Cite

Current views of psychological therapies for trauma typically assume the traumatic event to be in the past. Yet, individuals who live in contexts of ongoing organized violence or experience intimate partner violence (IPV) may continue to be (re)exposed to related traumatic events or have realistic fears of their recurrence. This systematic review considers the effectiveness, feasibility, and adaptations of psychological interventions for individuals living with ongoing threat. PsychINFO, MEDLINE, and EMBASE were searched for articles that examined psychological interventions in contexts of ongoing threat of either IPV or organized violence and used trauma-related outcome measures. The search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data on study population, ongoing threat setting and design, intervention components, evaluation methods, and outcomes were extracted, and study quality was assessed using the Mixed-Method Appraisal Tool. Eighteen papers featuring 15 trials were included (12 on organized violence and 3 on IPV). For organized violence, most studies showed moderate to large effects in reducing trauma-related symptoms when compared to waitlists. For IPV, findings were varied. Most studies made adaptations related to culture and ongoing threat and found that providing psychological interventions was feasible. The findings, albeit preliminary with mixed methodological quality, showed psychological treatments can be beneficial and should not be withheld in the context of ongoing organized violence and IPV. Clinical and research recommendations are discussed.

show abstract

Section: Adultsmentioning

confidence: 99%

The Effectiveness and Feasibility of Psychological Interventions for Populations Under Ongoing Threat: A Systematic Review

Yim

Lorenz

Šalkovskis

2023

Trauma, Violence, & Abuse

View full text Add to dashboard Cite

show abstract

“…Most recently, in 2023, Wilker et al found that methylation on the cg25535999 CpG site of the NR3C1 intron is negatively associated with PTSD symptoms (however, this study lacks data on GR expression level) [62]. Other epigenetic markers have been proposed to be associated with recovery or the prediction of treatment response [36,[63][64][65][66][67][68][69]. Lastly, in 2021 Vinkers et al revealed the possibility of reversing DNA methylation at the ZFP57 gene as a treatment for PTSD, opening the window to a new method of PTSD and psychiatric disorder treatment via epigenetics [36].…”

Section: Future Directions and Usementioning

confidence: 93%

Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder

Chou,

Huang,

2024

Life

View full text Add to dashboard Cite

Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes debilitating functional impairment in patients. Observations from survivors of traumatic historical events solidify that this disease is not only associated with personal experiences but can also be inherited from familial traumas. Over the past decades, researchers have focused on epigenetic inheritance to understand how responses to adverse experiences can be passed down to future generations. This review aims to present recent findings on epigenetic markers related to PTSD and research in the intergenerational inheritance of trauma. By understanding the information, we hope that epigenetic markers can act as biochemical measurements for future clinical practice.

show abstract

“…Xulu et al ( 66 ) applied NET as a forensic offender rehabilitation (FORNET) intervention in order to investigate DNA methylation changes associated PTSD treatment response and appetitive aggression symptoms among South African men. Participants with chronic trauma exposure received one of three interventions: FORNET, CBT or no intervention (waitlist).…”

Section: Epigenetic Mechanisms Underlying Post-traumatic Stress Disor...mentioning

confidence: 99%

A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment

et al. 2022

View full text Add to dashboard Cite

Epigenetic research in post-traumatic stress disorder (PTSD) is essential, given that environmental stressors and fear play such a crucial role in its development. As such, it may provide a framework for understanding individual differences in the prevalence of the disorder and in treatment response. This paper reviews the epigenetic markers associated with PTSD and its treatment, including candidate genes and epigenome-wide studies. Because the etiopathogenesis of PTSD rests heavily on learning and memory, we also draw upon animal neuroepigenetic research on the acquisition, update and erasure of fear memory, focusing on the mechanisms associated with memory reconsolidation. Reconsolidation blockade (or impairment) treatment in PTSD has been studied in clinical trials and, from a neurological perspective, may hold promise for identifying epigenetic markers of successful therapy. We conclude this paper by discussing several key considerations and challenges in epigenetic research on PTSD in humans.

show abstract

DNA methylation and psychotherapy response in trauma-exposed men with appetitive aggression

Cited by 8 publications

References 80 publications

The Effectiveness and Feasibility of Psychological Interventions for Populations Under Ongoing Threat: A Systematic Review

The Effectiveness and Feasibility of Psychological Interventions for Populations Under Ongoing Threat: A Systematic Review

Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder

A narrative review of the epigenetics of post-traumatic stress disorder and post-traumatic stress disorder treatment

Contact Info

Product

Resources

About