DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis
Tomoki Yamamoto,
Min Gi,
Satoshi Yamashita
et al.
Abstract:Arsenic is a known human urinary bladder carcinogen. While arsenic is known to cause aberrant DNA methylation, the mechanism of arsenic-triggered bladder carcinogenesis is not fully understood. The goal of this study was to identify aberrant DNA methylation in rat bladder urothelial carcinoma (UC) induced by dimethylarsinic acid (DMAV), a major organic metabolite of arsenic. We performed genome-wide DNA methylation and microarray gene expression analyses of DMAV-induced rat UCs and the urothelium of rats treat… Show more
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