DNA-Lipids-Me2+ Complexes Structure and their Possible Functions in a Cell

Abstract

Study of lipid-nucleic acids interactions have fifty years of history and were originally aimed at studying of DNAmembrane complexes (DMC). On the basis of own and literary data we had been proposed DMC model and their participation in the formation of structures nucleoid and nuclear envelope with pores.Understanding of nuclear pores role not only as channels between nucleus and cytoplasm but also as basic regulator of gene expression will allow using this knowledge in nanobiotechnology and medicine, in particular in gene therapy. In gene therapy the basic method of genes transfer in cells are complexes of DNA with which are strongly toxic for man. Zwitterionic lipids compose to 50 weight % of membranes and besides participation in DMC formation can really substitute cationic surfactants as carrier of DNA in cells.