Abstract:Crosslinking agents such as psoralens, nitrogen mustards or cisplatin are bifunctionally acting chemicals that generate some adducts as covalent linkages between complementary deoxyribonucleic acid strands. Since many agents are of importance in genetic toxicology and cancer therapy, repair of interstrand crosslinks has been studied extensively in bacteria and in lower and higher eukaryotes. The main repair pathway in
Escherichia coli
involves the sequential action of nucleotide exc… Show more
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