DNA interaction of [Cu(dmp)(phen-dion)] (dmp=4,7 and 2,9 dimethyl phenanthroline, phen-dion=1,10-phenanthroline-5,6-dion) complexes and DNA-based electrochemical biosensor using chitosan–carbon nanotubes composite film

Kashanian, Soheila; Khodaei, Mohammad Mehdi; Roshanfekr, Hamideh; Peyman, Hossein

doi:10.1016/j.saa.2013.05.091

Cited by 11 publications

(3 citation statements)

References 55 publications

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“…In recent years, 2,9-dimethyl-phenanthroline (dmphen), as a usual derivative of 1,10-phenanthroline, has been widely employed in many aspectso fc oordinational chemistry [1][2][3][4][5], supermolecular chemistry [6][7] and bioinorganic chemistry [8]. Combined with other aromatic coordinating ligands, dmphen has been used to enhancethe characters of theirmetal complexs [1].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9- dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate, C28H26N2NiO10

Guo

Zhang

2014

Zeitschrift Für Kristallographie - New Crystal Structures

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C 28 H 26 N 2 NiO 10 ,monoclinic, P2 1 /n (no. 14), a =9.4921(9) Å, Source of materialTo asolution of 2,9-dimethyl-1,10-phenanthroline hemihydrate (0.5 mmol), 2,4-hydroxybenzoate (0.5 mmol) and sodium hydroxide (0.5 mmol) in water/ethanol(v:v=2:1, 15 ml) was added a solution of Ni(NO 3 ) 2 ×6H 2 O(0.5 mmol) in distilled water (5 ml). The resulting solution was refluxed for 10 hat333 Kand filtrated. Blue single crystals of the title compound were obtained by slow evaporation of the filtrate over four weeks.

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Section: Discussionmentioning

confidence: 99%

Crystal structure of diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9- dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate, C28H26N2NiO10

Guo

Zhang

2014

Zeitschrift Für Kristallographie - New Crystal Structures

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“…reported that a chitosan-CNT-modified GCE electrode can be used in conjunction with the copper probe molecule [Cu(2,9-dimethyl-1,10-phenanthroline)(1,10-phenanthroline-5,6-dion)Cl]Cl . The ssDNA or dsDNA was immobilized onto the modified electrode surface, and then [Cu(2,9-dimethyl-1,10-phenanthroline)(1,10-phenanthroline-5,6-dion)Cl]Cl was introduced with a concentration of 20 μM . Considerably larger and well-defined redox peaks are observed for dsDNA than ssDNA, which indicates that the copper complex binds preferentially to the dsDNA-immobilized electrode surface.…”

Section: Overview Of Carbon-based Voltammetric Biosensorsmentioning

confidence: 99%

“…To differentiate between singlestranded DNA (ssDNA) and double-stranded DNA (dsDNA), Kashanian et 244 The ssDNA or dsDNA was immobilized onto the modified electrode surface, and then [Cu(2,9-dimethyl-1,10phenanthroline)(1,10-phenanthroline-5,6-dion)Cl]Cl was introduced with a concentration of 20 μM. 268 Considerably larger and well-defined redox peaks are observed for dsDNA than ssDNA, which indicates that the copper complex binds preferentially to the dsDNA-immobilized electrode surface. This indirect method can, as such, be used to electrochemically discriminate between dsDNA and ssDNA.…”

Section: Overview Of Carbon-based Voltammetric Biosensorsmentioning

confidence: 99%

Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

et al. 2015

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The study of electrochemical behavior of bioactive molecules has become one of the most rapidly developing scientific fields. Biotechnology and biomedical engineering fields have a vested interest in constructing more precise and accurate voltammetric/amperometric biosensors. One rapidly growing area of biosensor design involves incorporation of carbon-based nanomaterials in working electrodes, such as one-dimensional carbon nanotubes, two-dimensional graphene, and graphene oxide. In this review article, we give a brief overview describing the voltammetric techniques and how these techniques are applied in biosensing, as well as the details surrounding important biosensing concepts of sensitivity and limits of detection. Building on these important concepts, we show how the sensitivity and limit of detection can be tuned by including carbon-based nanomaterials in the fabrication of biosensors. The sensing of biomolecules including glucose, dopamine, proteins, enzymes, uric acid, DNA, RNA, and H2O2 traditionally employs enzymes in detection; however, these enzymes denature easily, and as such, enzymeless methods are highly desired. Here we draw an important distinction between enzymeless and enzyme-containing carbon-nanomaterial-based biosensors. The review ends with an outlook of future concepts that can be employed in biosensor fabrication, as well as limitations of already proposed materials and how such sensing can be enhanced. As such, this review can act as a roadmap to guide researchers toward concepts that can be employed in the design of next generation biosensors, while also highlighting the current advancements in the field.

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DNA binding, DNA cleavage and HSA interaction of several metal complexes containing N-(2-hydroxyethyl)-N′-benzoylthiourea and 1,10-phenanthroline ligands

Peng

Gao

et al. 2016

J Biol Inorg Chem

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Four novel ternary metal complexes of the type [M(Phen)(L1)2)] [phen = 1,10-phenanthroline, L1 = N-(2-hydroxyethyl)-N'-benzoylthiourea, M = Ni(II)(1), Co(II) (2), Cu(II) (3), Pd(II) (4)] were synthesized. The organic ligands and their corresponding organometallic complexes have been characterized using UV-vis absorption spectroscopy, element analysis, infrared radiation spectroscopy and fluorescence spectra. DNA binding and cleavage studies of these complexes were conducted in detail. In vitro DNA-binding properties were studied by electronic absorption spectra and fluorescence spectra methods. The results indicate that all of the ternary metal complexes can efficiently bind to DNA via intercalation mode. The DNA-binding constants for all ternary compounds are around 4 × 10(6) M(-1). The binding propensity of the complexes to human serum albumin (HSA) was also investigated. Agarose gel electrophoresis study revealed that the metal complexes could cleave super-coiled pBR322 DNA to a nicked form in the absence of external agents. In vitro anti bacterial studies show that copper complex has weak antibacterial activities. Copper complex exhibits a better biological activity among all complexes. This study provides a new perspective and evaluation on the role and importance of the effect factors on the medicinal properties of benzoylthiourea compounds. Synchronous fluorescence spectra of HSA (10 μM) as a function of concentration of the complexes 1-4.

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DNA interaction of [Cu(dmp)(phen-dion)] (dmp=4,7 and 2,9 dimethyl phenanthroline, phen-dion=1,10-phenanthroline-5,6-dion) complexes and DNA-based electrochemical biosensor using chitosan–carbon nanotubes composite film

Cited by 11 publications

References 55 publications

Crystal structure of diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9- dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate, C28H26N2NiO10

Crystal structure of diaqua-(2,4-dihydroxybenzoato-κ2O,O')-(2,9- dimethyl-1,10-phenanthroline-κ2N,N') nickel(II) 2,4-dihydroxybenzoate, C28H26N2NiO10

Engineered Carbon-Nanomaterial-Based Electrochemical Sensors for Biomolecules

DNA binding, DNA cleavage and HSA interaction of several metal complexes containing N-(2-hydroxyethyl)-N′-benzoylthiourea and 1,10-phenanthroline ligands

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