DNA Immobilization on GaP(100) Investigated by Kelvin Probe Force Microscopy

Richards, David; Zemlyanov, Dmitry; Asrar, Rafay M.; Chokshi, Yena Y.; Cook, Emily M.; Hinton, Thomas J.; Lu, Xinran; Nguyen, Viet Quoc; Patel, Neil K.; Usher, Jonathan R.; Vaidyanathan, Sriram; Yeung, David A.; Ivanisevic, Albena

doi:10.1021/jp105927t

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…[4] Although the bulk properties are controlled by the overall quality of the crystal by dopants used and/or defects present, the surface interface ultimately controls properties such as electrical conductivity, [5,6] chemical selectivity, [7] optical recombination events, [8] and environmental stability. [9] The inherent need to reduce the total surface energy drives the natural reduction of dangling bonds [10,11] which-in the presence of organic functional groups-form chemically adsorbed layers.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Stability of Functionalized GaN and GaP

et al. 2015

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Surface functionalization via 1 H,1 H,2 H,2H-perfluoro octanephosphonic acid was done in the presence of phosphoric acid to provide a simplified surface passivation technique for gallium nitride (GaN) and gallium phosphide (GaP). In an effort to identify the leading causes of surface instabilities, hydrogen peroxide was utilized as an additional chemical modification to cap unsatisfied bonds. The stability of the surfaces was studied in an aqueous environment and subsequently characterized. A physical characterization was carried out to evaluate the surface roughness and water hydrophobicity pre and post stability testing via atomic force microscopy and water goniometry. Surface-chemistry changes and solution leaching were quantified by X-ray photoelectron spectroscopy and inductively coupled plasma mass spectrometry. The results indicate a sensitivity to hydroxyl terminated species for both GaN and GaP under aqueous environments, as the increase of the degree of leaching was more significant for hydrogen peroxide treated samples. The results support the notion that hydroxyl species act as precursors to gallium oxide formation and lead to subsequent instability in aqueous solutions.

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Section: Introductionmentioning

confidence: 99%

Comparison of the Stability of Functionalized GaN and GaP

et al. 2015

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“…KPFM has been proposed as a way to quantitatively measure how much amount of linkers or biomolecules are immobilized on the nanomaterial or the device [100]. Richards and coworkers performed the immobilization of DNA on GaP substrate and measured the surface potential of the substrate surface before and after the immobilization [35]. The GaP surfaces patterned with 10, 20, and 30% undecenoic acid (UDA) by PDMS stamp were prepared.…”

Section: Label-free Nucleotides Analysismentioning

confidence: 99%

Surface Potential Analysis of Nanoscale Biomaterials and Devices Using Kelvin Probe Force Microscopy

Lee

et al. 2016

Journal of Nanomaterials

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In recent years, Kelvin probe force microscopy (KPFM) has emerged as a versatile toolkit for exploring electrical properties on a broad range of nanobiomaterials and molecules. An analysis using KPFM can provide valuable sample information including surface potential and work function of a certain material. Accordingly, KPFM has been widely used in the areas of material science, electronics, and biomedical science. In this review, we will briefly explain the setup of KPFM and its measuring principle and then survey representative results of various KPFM applications ranging from material analysis to device analysis. Finally, we will discuss some possibilities of KPFM on whether it is applicable to various sensor systems. Our perspective shed unique light on how KPFM can be used as a biosensor as well as equipment to measure electrical properties of materials and to recognize various molecular interactions.

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“…Surface functionalization seeks to control the surface chemistry of materials to avoid undesirable characteristics2 that may result from nonradiative recombination centers3 and high carrier recombination velocities from incomplete surface termination 4. Although the bulk properties are controlled by the overall quality of the crystal by dopants used and/or defects present, the surface interface ultimately controls properties such as electrical conductivity,5, 6 chemical selectivity,7 optical recombination events,8 and environmental stability 9. The inherent need to reduce the total surface energy drives the natural reduction of dangling bonds10, 11 which—in the presence of organic functional groups—form chemically adsorbed layers 12.…”

Section: Introductionmentioning

confidence: 99%

(−)‐Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies

et al. 2015

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Natural products containing the α,β-unsaturated δ-lactone skeleton have been shown to possess a variety of biological activities. The natural product (-)-tarchonanthuslactone (1) possessing this privileged scaffold is a popular synthetic target, but its biological activity remains underexplored. Herein, the total syntheses of dihydropyran-2-ones modeled on the structure of 1 were undertaken. These compounds were obtained in overall yields of 17-21 % based on the Keck asymmetric allylation reaction and were evaluated in vitro against eight different cultured human tumor cell lines. We further conducted initial investigation into the mechanism of action of selected analogues. Dihydropyran-2-one 8 [(S,E)-(6-oxo-3,6-dihydro-2H-pyran-2-yl)methyl 3-(3,4-dihydroxyphenyl)acrylate], a simplified analogue of (-)-tarchonanthuslactone (1) bearing an additional electrophilic site and a catechol system, was the most cytotoxic and selective compound against six of the eight cancer cell lines analyzed, including the pancreatic cancer cell line. Preliminary studies on the mechanism of action of compound 8 on pancreatic cancer demonstrated that apoptotic cell death takes place mediated by an increase in the level of reactive oxygen species. It appears as though compound 8, possessing two Michael acceptors and a catechol system, may be a promising scaffold for the selective killing of cancer cells, and thus, it deserves further investigation to determine its potential for cancer therapy.

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DNA Immobilization on GaP(100) Investigated by Kelvin Probe Force Microscopy

Cited by 11 publications

References 27 publications

Comparison of the Stability of Functionalized GaN and GaP

Comparison of the Stability of Functionalized GaN and GaP

Surface Potential Analysis of Nanoscale Biomaterials and Devices Using Kelvin Probe Force Microscopy

(−)‐Tarchonanthuslactone: Design of New Analogues, Evaluation of their Antiproliferative Activity on Cancer Cell Lines, and Preliminary Mechanistic Studies

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