DNA Hydrogels in the Perspective of Mechanical Properties

Cao, Dengjie; Xie, Yujie; Song, Jie

doi:10.1002/marc.202200281

Cited by 14 publications

(9 citation statements)

References 124 publications

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“…DNA hydrogels are highly compatible with 3D living cell bioprinting techniques due to their non-bendable double helix structure, allowing for excellent molecular permeability and better cell metabolism and nutrient delivery compared to traditional chemically cross-linked hydrogels (Figure 9c). [128,129] The structural dynamics of DNA hydrogels, such as thixotropy and self-healing properties, are conducive to cell culture, allowing for increased cell proliferation and migration. [130] The use of DNA hydrogels for constructing joint organoids is a promising approach as they can imitate the natural ECM by offering a physically restricted and nutrient-permeable space for cell growth, which makes them an excellent option (Figure 9d).…”

Section: Basic Joint Organoidsmentioning

confidence: 99%

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Small Joint Organoids 3D Bioprinting: Construction Strategy and Application

Zhang,

Li,

Wang

et al. 2023

Small

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Osteoarthritis (OA) is a chronic disease that causes pain and disability in adults, affecting ≈300 million people worldwide. It is caused by damage to cartilage, including cellular inflammation and destruction of the extracellular matrix (ECM), leading to limited self‐repairing ability due to the lack of blood vessels and nerves in the cartilage tissue. Organoid technology has emerged as a promising approach for cartilage repair, but constructing joint organoids with their complex structures and special mechanisms is still challenging. To overcome these boundaries, 3D bioprinting technology allows for the precise design of physiologically relevant joint organoids, including shape, structure, mechanical properties, cellular arrangement, and biological cues to mimic natural joint tissue. In this review, the authors will introduce the biological structure of joint tissues, summarize key procedures in 3D bioprinting for cartilage repair, and propose strategies for constructing joint organoids using 3D bioprinting. The authors also discuss the challenges of using joint organoids’ approaches and perspectives on their future applications, opening opportunities to model joint tissues and response to joint disease treatment.

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Section: Basic Joint Organoidsmentioning

confidence: 99%

Section: Constructive Strategies Of 3d Bioprinted Joint Organoidsmentioning

confidence: 99%

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Small Joint Organoids 3D Bioprinting: Construction Strategy and Application

Zhang,

Li,

Wang

et al. 2023

Small

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“…Therefore, the shear-thinning and reversibility of DNA hydrogels offer unexpected interest to flexible robotics, biotherapeutics, and other fields. [46] Yang et al developed a super-soft and super-elastic DNA hydrogel-based soft robot by adding magnetic nanoparticles (MNPs) to rolling circle amplication (RCA)prepared hydrogels. [34] Due to the shear-thinning properties, the hydrogel presented shape adaptability and could complete a series of complex magnetically driven navigation movements under the action of a certain magnetic field, and can also be used as a carrier to target the delivery of cells, drugs, etc.…”

Section: Strengthening Mechanical Properties Of Dna Hydrogelsmentioning

confidence: 99%

“…Therefore, the shear‐thinning and reversibility of DNA hydrogels offer unexpected interest to flexible robotics, biotherapeutics, and other fields. [ 46 ] Yang et al. developed a super‐soft and super‐elastic DNA hydrogel‐based soft robot by adding magnetic nanoparticles (MNPs) to rolling circle amplication (RCA)‐prepared hydrogels.…”

Section: Functional Regulation Of Functional Dna Hydrogels Based On N...mentioning

confidence: 99%

Preparation Strategies, Functional Regulation, and Applications of Multifunctional Nanomaterials‐Based DNA Hydrogels

Qiao,

Zhao,

Zhang

et al. 2023

Small Methods

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With the extensive attention of DNA hydrogels in biomedicine, biomaterial, and other research fields, more and more functional DNA hydrogels have emerged to match the various needs. Incorporating nanomaterials into the hydrogel network is an emerging strategy for functional DNA hydrogel construction. Surprisingly, nanomaterials‐based DNA hydrogels can be engineered to possess favorable properties, such as dynamic mechanical properties, excellent optical properties, particular electrical properties, perfect encapsulation properties, improved magnetic properties, and enhanced antibacterial properties. Herein, the preparation strategies of nanomaterials‐based DNA hydrogels are first highlighted and then different nanomaterial designs are used to demonstrate the functional regulation of DNA hydrogels to achieve specific properties. Subsequently, representative applications in biosensing, drug delivery, cell culture, and environmental protection are introduced with some selected examples. Finally, the current challenges and prospects are elaborated. The study envisions that this review will provide an insightful perspective for the further development of functional DNA hydrogels.

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DNA‐Intercalating Supramolecular Hydrogels for Tunable Thermal and Viscoelastic Properties

Hughes,

Aykanat,

Pierini

et al. 2024

Angewandte Chemie

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Polymeric supramolecular hydrogels (PSHs) leverage the thermodynamic and kinetic properties of non‐covalent interactions between polymer chains to govern their structural characteristics. As these materials are formed via endothermic or exothermic equilibria, their thermal response is challenging to control without drastically changing the nature of the chemistry used to join them. In this study, we introduce a novel class of PSHs utilizing the intercalation of double‐stranded DNA (dsDNA) as the primary dynamic non‐covalent interaction. The resulting dsDNA intercalating supramolecular hydrogels (DISHs) can be tuned to exhibit both endothermically or exothermically driven binding through strategic selection of intercalators. Bifunctional polyethylene glycol (MW ~ 2000 Da) capped with intercalators of varying hydrophobicity, charge, and size (acridine, psoralen, thiazole orange, and phenanthridine) produced DISHs with comparable moduli (500 ‐ 1000 Pa) but unique thermal viscoelastic response. Notably, acridine‐based cross‐linkers displayed invariant and even increasing elasticity with temperature, suggesting an endothermic binding mechanism. This methodology expands the set of structure‐properties available to biomass‐derived DNA biomaterials and promises a new material system where a broad set of thermal and viscoelastic responses can be obtained due to the sheer number and variety of intercalating molecules.

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DNA Hydrogels in the Perspective of Mechanical Properties

Cited by 14 publications

References 124 publications

Small Joint Organoids 3D Bioprinting: Construction Strategy and Application

Small Joint Organoids 3D Bioprinting: Construction Strategy and Application

Preparation Strategies, Functional Regulation, and Applications of Multifunctional Nanomaterials‐Based DNA Hydrogels

DNA‐Intercalating Supramolecular Hydrogels for Tunable Thermal and Viscoelastic Properties

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