DNA hybridisation of cervical scrapes: comparison with cytological findings in Papanicolaou smears.

Koilocytosis; an indication for conservative management

“…Several features are known to be associated with the infection, including dyskeratosis, parakeratosis, bi-and multinucleation and the presence of koilocytes. Of these, koilocytosis is the only truly diagnostic feature, and although we know from Morse et al 15 that by relying on the presence of koilocytes only the infection will be underdiagnosed, the obverse is also true and reliance on other factors leads to overdiagnosis. In our department we use koilocytosis alone as a criterion of active wart virus infection using criteria laid down by Meisels 13,14 .…”

Low Grade Cervical Intraepithelial Neoplasia Associated with Human Papillomavirus Infection

“…However, cytologic diagnosis of HPV infection was considered to have low sensitivity as compared with HPV DNA study. 26,37 In the present study, cytologic diagnosis of HPV infection correlated somewhat with HPV DNA by Vira Pap. Negative cytologic diagnoses of HPV infection correlated fairly well with the results of Vira Pap study (23 negative HPV DNA cases among 34 negative cytologic cases), but positive cytologic diagnoses did not correlate with the results of Vira Pap study (five positive HPV DNA cases in nine positive cytology cases).…”

“…HPV DNA was negative in 81% ( performed by koilocytosis, parakeratosis, smudged nuclei and multinuclei. [21][22][23]26 Because cytologic examination is a valuable and convenient method for the clinician, it is very useful if evaluation of HPV infection can be done by cytologic examination. The correlation between the cytologic diagnosis of HPV infection and HPV DNA study by Vira Pap was examined.…”

Factors associated with clinical and sub-clinical anal human papillomavirus infection in homosexual men.

“…However, in a comparable study of anal scrape material Kiviat et al found HPV DNA in only 17% of their 101 specimens26; and Morse et al, in their comparison of DNA hybridisation and cytology in cervical scapes, found detectable HPV DNA in only 39% of scrapes whereas cytological changes suggestive of HPV infection were present in 41%. 22 In summary, it is apparent that no particular diagnostic method is ideal for detecting HPV infection of the anal canal, since a marked lack of correlation was found between clinical criteria, cytology and HPV DNA hybridisation. The percentage of positive cases detected by the different diagnostic methods (using the figure of 73 positive cases as the denominator) was as follows: clinical examination 40%; cytological examination 71 %; and DNA hybridisation 62%.…”